Marina Simón
Paris Descartes University
9 Papers
6 Citations
Marina Simón is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Medicine & Chagas disease. The author has an hindex of 3, co-authored 6 publications. Previous affiliations of Marina Simón include University of Paris & French Institute of Health and Medical Research.
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Papers
SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat.
TL;DR: Treatment of Darier keratinocytes with the orphan drug Miglustat, a pharmacological chaperone, restored mature AJ and desmosome formation, and improved adhesion strength, point to an important contribution of ER stress in DD pathogenesis.
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A proportion of CD4+ T cells from patients with chronic Chagas disease undergo a dysfunctional process, which is partially reversed by benznidazole treatment
Elena Pérez-Antón,Adriana Egui,M. Carmen Thomas,Bartolomé Carrilero,Marina Simón,Miguel Ángel López-Ruz,Manuel Segovia,Manuel Carlos López +7 more
TL;DR: A CD4+ T cell dysfunctional process was detected in chronic Chagas disease patients, being more exacerbated in those patients with cardiac symptoms, and after short-term benznidazole treatment, indeterminate patients showed a significant increase in the frequency of multifunctional antigen-specific CD4- T cells.
Differential phenotypic and functional profile of epitope-specific cytotoxic CD8+ T cells in benznidazole-treated chronic asymptomatic Chagas disease patients.
Adriana Egui,Manuel Carlos López,Inmaculada Gómez,Marina Simón,Manuel Segovia,M. Carmen Thomas +5 more
TL;DR: There is a differential memory CD8+ T cell profile depending on the antigenic epitope and that the benznidazole treatment modulates the memory, differentiation and senescence phenotypes of the epitope-specific CD8- T cells.
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Differential expression profile of genes involved in the immune response associated to progression of chronic Chagas disease.
Inmaculada Gómez,Manuel Carlos López,Adriana Egui,Génesis Palacios,Bartolomé Carrilero,Celia Benitez,Marina Simón,Manuel Segovia,Emma Carmelo,María del Carmen Thomas +9 more
TL;DR: In this paper , the expression patterns of genes involved in relevant immunological processes throughout the disease in patients with chronic Chagas disease were investigated using high-throughput RT-qPCR with QuantStudio 12K Flex real-time PCR system.
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Chemiluminescent Microparticle Immunoassay for the Diagnosis of Congenital Chagas Disease: A Prospective Study in Spain.
TL;DR: In this paper, the authors show that CMIA assay is a great diagnostic tool as a single serological test at 9 months of age to rule out CCD or to identify possible transmission.
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