Mariko Tsukagoshi
Gunma University
106 Papers
151 Citations
Mariko Tsukagoshi is an academic researcher from Gunma University. The author has contributed to research in topics: Medicine & Hepatectomy. The author has an hindex of 12, co-authored 75 publications.
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Papers
Functional remnant liver volumetry using Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) predicts post-hepatectomy liver failure in resection of more than one segment
Kenichiro Araki,Norifumi Harimoto,Norio Kubo,Akira Watanabe,Takamichi Igarashi,Mariko Tsukagoshi,Norihiro Ishii,Yoshito Tsushima,Ken Shirabe +8 more
TL;DR: FRLV using LMR could precisely predict post-hepatectomy liver failure (PHLF) in resection of more than one segment, and was useful even in patients who underwent PVE.
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Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts
Takahiro Yamanaka,Norifumi Harimoto,Takehiko Yokobori,Ryo Muranushi,Kouki Hoshino,Kei Hagiwara,Dolgormaa Gantumur,Tadashi Handa,Norihiro Ishii,Mariko Tsukagoshi,Takamichi Igarashi,Hiroshi Tanaka,Akira Watanabe,Norio Kubo,Kenichiro Araki,Ken Shirabe +15 more
TL;DR: The findings suggest that therapeutic strategies combining conventional cytotoxic agents with nintedanib targeting CAFs are promising for overcoming refractory ICC with activated CAFs.
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Diagnostic value of 18F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8+tumour-infiltrating lymphocytes in oral squamous cell carcinoma.
Maria Togo,Takehiko Yokobori,Kimihiro Shimizu,Tadashi Handa,Kyoichi Kaira,Takaaki Sano,Mariko Tsukagoshi,Tetsuya Higuchi,Satoshi Yokoo,Ken Shirabe,Tetsunari Oyama +10 more
TL;DR: Cold tumour phenotypes as low PD-L1 tumour cells and low stromal CD8 correlated with the poor prognosis, high 18F-FDG-uptake and E-cadherin suppression was an independent predictor of the cold tumour immune status.
High Stromal TGFBI in Lung Cancer and Intratumoral CD8-Positive T Cells were Associated with Poor Prognosis and Therapeutic Resistance to Immune Checkpoint Inhibitors.
Nobuhiro Nakazawa,Takehiko Yokobori,Kyoichi Kaira,Andrei Turtoi,Seded Baatar,Navchaa Gombodorj,Tadashi Handa,Mariko Tsukagoshi,Yasunari Ubukata,Akiharu Kimura,Norimichi Kogure,Kyoichi Ogata,Toshitaka Maeno,Makoto Sohda,Toshiki Yajima,Kimihiro Shimizu,Akira Mogi,Hiroyuki Kuwano,Hiroshi Saeki,Ken Shirabe +19 more
TL;DR: The dual evaluation of stromal TGFBI and intratumoral CD8-positive T cells could be a useful predictive marker for nivolumab.
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Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.
Norihiro Ishii,Kenichiro Araki,Takehiko Yokobori,Kei Hagiwara,Dorgormaa Gantumur,Takahiro Yamanaka,Tadashi Handa,Mariko Tsukagoshi,Takamichi Igarashi,Akira Watanabe,Norio Kubo,Norifumi Harimoto,Atsushi Masamune,Kazuo Umezawa,Hiroyuki Kuwano,Ken Shirabe +15 more
TL;DR: It is shown that cancer‐associated fibroblasts (CAF) stimulated indicators of pancreatic cancer malignancy, such as proliferation, invasiveness, and chemoresistance, and that CnP suppressed CAF activity and proliferation, and inhibited the stimulating effects of CAF on pancreatic cancers cells.
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