Marieka V. DeVuono
University of Guelph
9 Papers
3 Citations
Marieka V. DeVuono is an academic researcher from University of Guelph. The author has contributed to research in topics: Cannabinoid hyperemesis syndrome & Cannabinoid. The author has an hindex of 5, co-authored 9 publications.
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Papers
Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms.
Marieka V. DeVuono,Linda A. Parker +1 more
- 05 Jun 2020
TL;DR: Extended high doses of the main psychotropic compound in cannabis result in changes to the endocannabinoid system by acting on the cannabinoid 1 (CB1) receptor, which may cause Cannabinoid hyperemesis syndrome.
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Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine.
Erin M. Rock,Samantha M. Ayoub,Cheryl L. Limebeer,Alexia Gene,Kiri L. Wills,Marieka V. DeVuono,Reem Smoum,Vincenzo Di Marzo,Aron H. Lichtman,Raphael Mechoulam,Linda A. Parker +10 more
TL;DR: The results suggest that the aversive effects of acute naloxone-precipitated MWD reflect nausea, which is suppressed by OlGly.
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Role of the stress response and the endocannabinoid system in Δ9-tetrahydrocannabinol (THC)-induced nausea
Marieka V. DeVuono,Olivia La Caprara,Megan T. Sullivan,Alexandra Bath,Gavin N. Petrie,Cheryl L. Limebeer,Erin M. Rock,Matthew N. Hill,Linda A. Parker +8 more
TL;DR: Treatments that interfere with the stress response also inhibit THC- induced conditioned gaping, but a typical anti-emetic drug does not, supporting the hypothesis that THC-induced nausea, and cannabinoid hyperemesis syndrome (CHS), is a result of a dysregulated stress response.
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Conditioned gaping produced by high dose Δ9-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system.
Marieka V. DeVuono,Kelly M. Hrelja,Lauren Sabaziotis,Alex Rajna,Erin M. Rock,Cheryl L. Limebeer,David M. Mutch,Linda A. Parker +7 more
TL;DR: The hypothesis that THC‐induced nausea is a result of a dysregulated hypothalamic‐pituitary‐adrenal axis leading to an overactive stress response is supported.
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Effect of footshock stress on place conditioning produced by Δ9-tetrahydrocannabinol and the fatty acid amide hydrolase (FAAH) inhibitor, URB597, in Sprague-Dawley rats
TL;DR: Unlike the effect of footshock on THC- and URB597-induced anxiolytic effects, footshock does not promote THC or URB598-induced reward in a conditioned place preference paradigm, but footshock stress reverses the sedative effects of 1 mg/kg THC.
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