Mariana Eppinger-Helft
Academia Nacional de Medicina
10 Papers
238 Citations
Mariana Eppinger-Helft is an academic researcher from Academia Nacional de Medicina. The author has contributed to research in topics: Vincristine & Maintenance therapy. The author has an hindex of 10, co-authored 10 publications.
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Papers
Evaluation of induction of remission, intensification, and central nervous system prophylactic treatment in acute lymphoblastic leukemia.
Federico Sackmann Muriel,Santiago Pavlovsky,Jorge A. Peñalver,Guillermo Hidalgo,Angela Cebrian Bonesana,Mariana Eppinger-Helft,Graciela H. de Macchi,Alfredo Pavlovsky +7 more
TL;DR: Adriamycin did not seem to be any better than Daunorubicin in inducing or prolonging complete remission when used in combination with vincristine and prednisone, either as induction treatment or in reinforcement courses, and the CNS prophylactic treatment employed in this trial is very effective in preventing CNS relapse, although it does not seems to prevent hematologic relapse.
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Factors that influence the appearance of central nervous system leukemia
TL;DR: CNS leukemia infiltration was more frequent in children with initial organomegaly and high WBC count at the time of diagnosis than in adults with ALL, and was significantly greater in patients with high initial peripheralWBC count.
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Evaluation of intensification and maintenance programs in the treatment of acute lymphoblastic leukemia.
Federico Sackmann-Muriel,Svarch E,Mariana Eppinger-Helft,J. L. Braier,Santiago Pavlovsky,Liliana Guman,Berta Vergara,Carlos Ponzinibbio,Renato Failace,Guy Garay,Enrique Bugnard,Felix G. Ojeda,Roberto de Bellis,Susana R. De Sijvarger,Jorge Saslavsky +14 more
TL;DR: The variables studied in this protocol did not show significant extension of complete remission, however the sum of them seems to offer some advantage; however, those who received intensification, daily maintenance and further intrathecal therapy behaved slightly better.
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Induction and maintenance of remission in acute leukemia
Santiago Pavlovsky,Jorge A. Peñalver,Mariana Eppinger-Helft,Federico Sackmann Muriel,Luis J. Bergna,Argimiro Suarez,Guillermo Vilaseca,Alberto Andino Pavlovsky,Alfredo Pavlovsky +8 more
TL;DR: There was no statistically significant difference between the two maintenance regimens of vincristine, daunorubicin, and prednisone for induction followed by consolidation courses every 6 months with these drugs and either 6‐mercaptopurine and methotrexate (plan A) or metotrexate alone (plan B) for maintenance of remission.
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Comparison of central nervous system prophylaxis with cranial radiation and intrathecal methotrexate versus intrathecal methotrexate alone in acute lymphoblastic leukemia
Federico Sackmann Muriel,Svarch E,Santiago Pavlovsky,Mariana Eppinger-Helft,Jorge Braier,Berta Vergara,Guy Garay,Rita Kvicala,Jorge M. Divito,Renato Failace,Eduardo Dibar,Elias Jimenez +11 more
TL;DR: A randomized study comparing the use of additional doses of i.t. MTX-DMT alone during induction plus 3 doses weekly during the first month of remission and every 3 mo thereafter concludes that it is not of further benefit in preventing CNS relapse.
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