Marian E. Major
Center for Biologics Evaluation and Research
56 Papers
538 Citations
Marian E. Major is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Hepatitis C virus & Antibody. The author has an hindex of 28, co-authored 54 publications. Previous affiliations of Marian E. Major include State Research Center of Virology and Biotechnology VECTOR & Food and Drug Administration.
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Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
Brett D. Lindenbach,Philip Meuleman,Alexander Ploss,Thomas Vanwolleghem,Andrew J. Syder,Jane A. McKeating,Robert E. Lanford,Stephen M. Feinstone,Marian E. Major,Geert Leroux-Roels,Charles M. Rice +10 more
TL;DR: It is reported here that HCVcc strain FL-J6/JFH can establish long-term infections in chimpanzees and in mice containing human liver grafts, and virus recovered from these animals was highly infectious in cell culture, demonstrating efficient ex vivo culture of HCV.
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The molecular virology of hepatitis C
Marian E. Major,S M Feinstone +1 more
TL;DR: The extensive secnomenclature defined six major genotypes (1-6) based upon ondary structure and the presence of several AUG triplets phylogenetic analyses of the core, E1, and NS5 regions before the authentic initiator codon have led to comparisons with further divisions into subtypes.
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Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver.
Jeonghoon Heo,Valentina M. Factor,Tania Uren,Yasushi Takahama,Ju Seog Lee,Marian E. Major,Stephen M. Feinstone,Snorri S. Thorgeirsson +7 more
TL;DR: A highly enriched population of committed hepatocyte precursors can be generated from ES cells in vitro for effective cell replacement therapy.
157
Mathematical modeling of primary hepatitis C infection: noncytolytic clearance and early blockage of virion production
Harel Dahari,Harel Dahari,Marian E. Major,Xinan Zhang,Kathleen Mihalik,Charles M. Rice,Alan S. Perelson,Alan S. Perelson,Stephen M. Feinstone,Avidan U. Neumann,Avidan U. Neumann +10 more
TL;DR: It is suggested that endogenous type I interferon slows virus production in the early acute phase of hepatitis C virus infection and correlates with the half-life of infected cells regulated by both cytolytic and noncy tolytic mechanisms.
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The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity
Michael Thomson,Michelina Nascimbeni,Michael B. Havert,Marian E. Major,Sophia Gonzales,Harvey J. Alter,Stephen M. Feinstone,Krishna K. Murthy,Barbara Rehermann,T. Jake Liang +9 more
TL;DR: The present study suggests that the outcome ofHCV infection in chimpanzees is not necessarily attributable to HCV sequence variation and that chimpanzees may recover from HCV infection by mechanisms other than the induction of readily detectable HCV-specific T-cell responses.
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