/pdf/biocompatibilidad-del-cianoacrilato-de-butilo-en-suturas-en-2vwo9nbglk.pdf

Biocompatibilidad del cianoacrilato de butilo en suturas en piel en comparación con las suturas convencionales

Introduction The use of tissue adhesives can be an alternative to suture fixation of the mesh, but experience in their use is very limited. Material and methods A prospective descriptive study was conducted on a group of 35 patients with inguinal hernias repaired by sutureless hernioplasty (20 by open and 15 by endoscopic), the prosthesis was fixed with a synthetic adhesive (n-hexyl-α-cyanoacrylate). This group was compared with another 35 patients for hernia repair with fixation sutures. All patients were scheduled for outpatient surgery. Peri-operative variables were recorded. The patients were followed up at one week, one month, 6 months and one year after surgery. Results There was no morbidity associated with the use of tissue adhesive (bruising, infection or skin necrosis). During a median follow-up of 15 months, no complications or recurrences were detected. In the open hernioplasty using adhesive significantly reduced surgery time (30 min versus 70 min, P=.001), postoperative pain (from 2.4 to 4.5 at one week, P Conclusion The use of a synthetic tissue adhesive (n-hexyl-α-cyanoacrylate) is safe as a means of fixation in uncomplicated hernia and patients without comorbidity, and with good postoperative results.

[Is sutureless hernia repair a safe option for treating abdominal wall hernias? A prospective study with a synthetic tissue adhesive (n-hexyl-alpha-cyanoacrylate)].

Resumen Introduccion El uso de adhesivos tisulares puede ser una alternativa a la sutura en la fijacion de la malla, pero su experiencia clinica es muy limitada. Material y metodos Estudio prospectivo y descriptivo en un grupo de 35 pacientes con hernias inguinales operados mediante hernioplastia sin sutura (20 via abierta y 15 via endoscopica); la protesis se fijo con adhesivo sintetico (n-hexil-α-cianoacrilato). Este grupo se ha comparado con uno control operado mediante hernioplastia utilizando suturas. Todos los pacientes seguian protocolo de cirugia mayor ambulatoria. Se han registrado variables peri- y postoperatorias. El seguimiento se realizo a la semana, al mes, a los 6 meses y al ano. Resultados No ha existido morbilidad asociada con el uso del adhesivo tisular. Durante una mediana de 15 meses no se han detectado complicaciones ni recurrencias. En la hernioplastia abierta el uso del adhesivo disminuye de forma significativa el tiempo quirurgico (30 min versus 62 min, p = 0,001), el dolor postoperatorio (de 2,4 a 4,5 a la semana, p  0,001). El analisis economico demuestra un ahorro anual de 117.461,2 euros (sobre 460 hernias). Conclusion El uso de un adhesivo tisular sintetico (n-hexil-α-cianocrilato) es seguro como medio de fijacion en las hernioplastias no complejas en pacientes sin comorbilidad, con buenos resultados postoperatorios.

¿Es segura la hernioplastia sin sutura como opción para tratar las hernias de pared abdominal? Estudio prospectivo con un adhesivo tisular sintético (n-hexil-α-cianoacrilato)

Introduction: N-Butyl-cyanoacrylate is a tissue-synthesis material. It offers countless advantages: short application time, easy execution, as well as possessing hemostatic character. This material is bacteriostatic, biodegradable, and exhibits suitable tensile strength. Objective: The objective of the present paper was the histological evaluation of n-butyl-cyanoacrylate biocompatibility on rats dorsum back (spine), compared to braided black silk and Polyglactin 910. Materials and Methods: Thirty six Wixtar albino rats were used for the procedure. They were randomly divided into four groups (A, B, C, D) related to the time of sacrifi ce (3rd, 7th, 14th and 21st day) respectively. On the rats’ spine, three 2 cm long incisions were performed. Histological parameters were as follows: polymorphonuclear cell inflammatory infiltrate, young fibroblasts and epidermis thickening. Results: N-butyl-cyanoacrylate caused lesser polymorphonuclear infi ltrate when compared to other used materials. Fibroblast proliferation peaked in groups treated with n-butyl-cyanoacrylate when compared to the rest. Epidermis thickening showed high mitotic ability of keratocytes to remodel epithelium. At the 14th and 21st days most tissues treated with N-Butyl-cyanoacrylate were found to be completely remodeled when compared to the rest. Conclusion: N-butyl-cyanoacrylate was shown to be the most biocompatible material, since it elicited shortest healing time.

Biocompatibilidad del cianoacrilato de butilo en suturas en piel en comparación con las suturas convencionales Biocompatibility of n-butyl-cyanoacrylate compared to conventional skin sutures in skin wounds

Summary Objective: We undertook this study to evaluate 2-octyl cyano- acrylate glue and suture for wound closure in the small bowel. Methods: This was a comparative and experimental study. Male and female domestic dogs (n = 10) underwent a 2.0-cm small bowel closure of two wounds. All of these had closure with 2- octyl cyanoacrylate in the first wound. The controls (second wound in the same dog) were closed with suture. Four weeks later the wounds were observed to evaluate the repair. Results: Wound closure time and macrophage count were lower with the 2-octyl cyanoacrylate glue than in the suture group. Conclusions: 2-Octyl cyanoacrylate glue has the strength to seal a small bowel wound. The inflammatory response to the glue is lower than that of the suture at 4 weeks. These properties may make it a suitable material for replacing suture in a small bowel wound.

/pdf/adhesivo-tisular-2-octil-cianoacrilato-en-el-cierre-de-dbk5do4x5b.pdf

Adhesivo tisular 2-octil cianoacrilato en el cierre de enterotomía comparado con sutura manual tradicional en dos capas. Modelo en perros

Se evaluó la utilidad del n-butil 2-cianoacrilato en microcirugía vascular, se comparó tiempo de sutura entre el adhesivo y el polipropileno 8/0, se valoró resistencia de la sutura, se determinó la permeabilidad de la anastomosis y se diferenció el comportamiento histológico vascular, en un estudio prospectivo aleatorio de cohorte (1 y 6 meses) en 65 ratas Wistar macho: controles sanos (n= 10), estudio (n= 28) y controles positivos (n= 27). Se aplicó cianoacrilato en aorta abdominal con 3 puntos de retención, se midió presión intraluminal por técnica barométrica convencional, se estudió la histología vascular y se comparó con la aplicación del comportamiento con el polipropileno 8/0. El tiempo de sutura vascular con el adhesivo fue de 836,29 ± 77,18 s y 2634,07 ± 97,30 s con el control positivo, con alta significación estadística (p < 0,000000); presión permitida con adhesivo, 296,95 ± 6,79 mmHg y 252,61±58,71 mmHg, en control positivo con alta significación estadística (p < 0,00544); efectividad de sutura 92,86 % con el cianoacrilato y 85,19 % con el polipropileno, sin diferencia entre ambos. Hubo degradación del cianoacrilato a los 6 meses. El n-butil 2cianoacrilato es más rápido de aplicar en la cirugía vascular, soporta más presión y no produce toxicidad.

Efectos locales de la aplicación del n-butil 2-cianoacrilato en la microcirugía vascular experimental

Biological assays in order to evaluate medical devices, biomateri- als and implants are regulated by specific norms which define how many of them had to be performed. Depending on the kind of application that you in- tend to give the material in study or time of contact between the equipment and the organism so will be the severity of the evaluation. In order to amplify the application of Tisuacryl to oral region, a skin adhesive of national production, composed by n-butyl cianoacrylic monomer for close surgical wounds, the evalua- tion of the irritation of the oral mucose was developed. Although a lot of na- tional and international rules exist in order to establish the methodology, no one is specific to the particular case of adhesives. Those kinds of monomers polymerize with facilities through contact with a lot of organic and inorganic

Efecto del Tisuacryl sobre la mucosa oral

Los alquilcianoacrilatos son la base de los adhesivos quirurgicos, industriales o domesticos. Su propiedad bacteriologica ha sido poco estudiada y por eso la bibliografia es escasa y antigua, con resultados en ocasiones discrepantes. En varias publicaciones se plantea que son bacteriostaticos o autoesteriles; en otras se ha detectado contaminacion. El conocimiento de las limitaciones de esta propiedad es muy importante para poder decidir el grado de esterilidad que se requiere para su produccion, asi como las medidas necesarias para su aplicacion. El objetivo fundamental del presente trabajo fue estudiar las caracteristicas como bacteriostatico, de forma comparativa, entre un adhesivo de produccion nacional y otro comercial. Para esto se utilizaron los metodos convencionales de siembra del microorganismo en placas y analisis de la evolucion del crecimiento bacteriano. Para ambos adhesivos se demostro que esta caracteristica no es generalizable, ya que varia en dependencia de la cepa utilizada, pero parece tener relacion con su biotransformacion.

/pdf/determinacion-in-vitro-del-poder-bacteriostatico-comparativo-13vpo73lop.pdf

Determinación in vitro del poder bacteriostático comparativo entre un adhesivo cianoacrílico de producción nacional y otro comercial

http://scielo.sld.cu/pdf/mil/v30n2/mil07201.pdf

Empleo de adhesivos cianoacrílicos en cirugía vascular

Se unificaron metodos de la quimica analitica mediante el uso de la espectroscopia infrarroja y evaluacion gravimetrica de los materiales antes y despues de entrar en contacto con el adhesivo y se evaluo el resultado estadisticamente mediante el analisis de la varianza y utilizando la t de Student. Se aprovecho el experimento para evaluar la adhesion e histotoxicidad sobre el tejido tratado. El objetivo fue implementar un metodo sensible y sencillo para evaluar estas interferencias. De los resultados se preve que estos materiales no seran utiles para el envase, pues todos presentan variacion significativa del peso. Se concluyo que el metodo es sensible y resulta adecuado para posteriores evaluaciones de otros materiales. El uso de tecnicas interdisciplinarias en un mismo experimento permite integrar resultados y asi obtener mayor informacion con un minimo de animales de experimentacion. El resultado pudiera ser de utilidad para la toxicologia regulatoria, pues no se dispone de normas vigentes para este tipo de evaluacion.

http://scielo.sld.cu/pdf/ibi/v23n4/ibi09404.pdf

Evaluación químico-biológica de diferentes materiales utilizados como envases de adhesivos quirúrgicos

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