Maria Edeling
University of Pennsylvania
5 Papers
Maria Edeling is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney & Hippo signaling pathway. The author has an hindex of 4, co-authored 4 publications.
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Papers
Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog
TL;DR: This work describes how three key developmental signalling pathways — Notch, Wnt and Hedgehog (Hh) — are reactivated in response to kidney injury and contribute to the fibrotic response.
Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells
Katharina Schütte-Nütgen,Maria Edeling,Gudrun Mendl,Michael P. Krahn,Bayram Edemir,Thomas Weide,Joachim Kremerskothen,Ulf Michgehl,Hermann Pavenstädt +8 more
TL;DR: It is shown that Dab2 expression in cultured tubular epithelial cells is involved in endocytic regulation and that it also protects cells from TGF‐β‐induced epithelial‐to‐mesenchymal transition and may impact on acute and CKDs.
9
Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury
Katharina Schütte-Nütgen,Maria Edeling,Dominik Kentrup,Barbara Heitplatz,Veerle Van Marck,Alexander Zarbock,Melanie Meersch-Dini,Hermann Pavenstädt,Stefan Reuter +8 more
TL;DR: In this article , the authors found that IL24 is upregulated in the kidney after renal ischemia-reperfusion injury and that tubular epithelial cells and infiltrating inflammatory cells are the source of IL24.
3
WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway.
Anke Hermann,Dirk Oliver Wennmann,Sascha Gromnitza,Maria Edeling,Veerle Van Marck,Marius Sudol,Liliana Schaefer,Kerstin Duning,Thomas Weide,Hermann Pavenstädt,Joachim Kremerskothen +10 more
TL;DR: It is shown that loss of hepatic WWC expression in mice leads to tissue overgrowth, inflammation, fibrosis, and formation of liver carcinoma, and expression of WWC proteins may serve as novel prognostic factors in human liver carcinomas.
Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation.
Thomas Weide,Beate Vollenbröker,Ulf Schulze,Ivona Djuric,Maria Edeling,Jakob Bonse,Florian Hochapfel,Olga Panichkina,Dirk-Oliver Wennmann,Britta George,Seonhee Kim,Christoph Daniel,Jochen Seggewiß,Kerstin Amann,Wilhelm Kriz,Michael P. Krahn,Hermann Pavenstädt +16 more
TL;DR: Findings support a link between apical polarity proteins and renal diseases, especially renal cyst diseases, and further investigation of the Pals1-linked networks is required to decipher the mechanisms underlying the pathogenesis of these diseases.