Maria E. Verdugo
Cornell University
3 Papers
33 Citations
Maria E. Verdugo is an academic researcher from Cornell University. The author has contributed to research in topics: Posterior segment of eyeball & Retinal pigment epithelium. The author has an hindex of 3, co-authored 3 publications.
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Papers
Age-related increase in activity of specific lysosomal enzymes in the human retinal pigment epithelium.
Maria E. Verdugo,Jharna Ray +1 more
TL;DR: Western blot analysis provides evidence for increased synthesis of beta-glucuronidase with aging, and a significant decrease of dermatan sulfate levels with aging correlates well with the observed increase in the level of alpha-mannosidase activity.
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Posterior segment approach for subretinal transplantation or injection in the canine model.
TL;DR: A posterior segment approach for cell transplantation or injection into the subretinal space of the dog has been developed, and light microscopy demonstrates the distribution of stable, viable RPE cells in the sub retinal space up to 6 months.
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Adenoviral vector-mediated beta-glucuronidase cDNA transfer to treat MPS VII RPE in vitro.
Maria E. Verdugo,Virginia Scarpino,Philippe Moullier,Mark E. Haskins,Gustavo D. Aguirre,Jharna Ray +5 more
TL;DR: Adenoviral vector could mediate transfer of G USB in MPS VII affected RPE and RPE of various species, and the expression was observed to be stable in vitro, however, controlled expression of GUSB was essential for the metabolism of stored GAGs to achieve normal levels.
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