Maria Anders
University Hospital Heidelberg
9 Papers
59 Citations
Maria Anders is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Virus & Infectivity. The author has an hindex of 8, co-authored 9 publications. Previous affiliations of Maria Anders include Heidelberg University.
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Papers
Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease
Dirk Jochmans,Dirk Jochmans,Maria Anders,Inge Keuleers,Liesbeth Smeulders,Hans-Georg Kräusslich,Günter Kraus,Barbara Müller +7 more
TL;DR: This work sought to exploit HIV protease (PR) related cytotoxicity in order to develop a strategy for drug induced killing of HIV producing cells and presented proof of concept for targeted drug induced elimination of HIV produce cells.
Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor.
Jiří Schimer,Marcela Pávová,Maria Anders,Petr Pachl,Pavel Šácha,Petr Cigler,Jan Weber,Pavel Majer,Pavlína Řezáčová,Hans-Georg Kräusslich,Barbara Müller,Jan Konvalinka +11 more
TL;DR: It is demonstrated that proteolysis of immature HIV particles produced in the presence of the inhibitor can be rapidly triggered by light enabling thus to analyze the timing, regulation and spatial requirements of viral processing in real time.
An expanded model of HIV cell entry phenotype based on multi-parameter single-cell data
Katarzyna Bozek,Manon Eckhardt,Manon Eckhardt,Saleta Sierra,Maria Anders,Rolf Kaiser,Hans-Georg Kräusslich,Barbara Müller,Thomas Lengauer +8 more
TL;DR: The development of an extended description of the HIV entry phenotype reflecting its co-dependence on several key determinants as the basis for a more accurate prediction of HIV-1 entry phenotype from genotypic data and a multivariate phenotype descriptor, termed phenotype vector, which facilitates a more detailed characterization of HIV entry phenotypes than currently used binary tropism classifications.
A simple fluorescence based assay for quantification of human immunodeficiency virus particle release
TL;DR: The fast and simple fluorescence based quantification of HIV particle release yielded reproducible results which were comparable to the well established ELISA measurements, while in addition allowing the parallel determination of intracellular Gag expression.
Induced Maturation of Human Immunodeficiency Virus
Simone Mattei,Maria Anders,Jan Konvalinka,Hans-Georg Kräusslich,Hans-Georg Kräusslich,John A. G. Briggs,Barbara Müller,Barbara Müller +7 more
TL;DR: An inhibitor washout strategy to synchronize activation of protease in wild-type virus is developed and it is demonstrated that nearly complete Gag processing and resolution of the immature virus architecture are accomplished under optimized conditions.