Margot Zöller

TL;DR: Serological analysis of cDNA expression libraries (SEREX) has proven to be a useful technique in the quest to elucidate the repertoire of immunogenic gene products in human cancer, and the method was applied to human renal cell carcinoma (RCC) in order to identify associated immunogenic genes products.

TL;DR: Five newly described metastasis-associated antigens share with CD44v the absence of expression on nonmetastasizing tumor lines as well as expression on distinct, nontransformed cells and induction of expression during ontogeny, suggesting that tumor progression may rather be initiated by inappropriate expression or up-regulation of genes, than by de novo appearance of "metastasis genes.

TL;DR: It is noted that in irradiated mice reconstituted with a bone marrow cell transplant, anti‐CD44 exerts a stronger effect on haematopoietic reconstitution than on T lymphoma (EL4) growth, and care should be taken not to interfere by a blockade of CD44 with haem atopoiesis, which could be circumvented by selectively targeting leukemic CD44 isoforms.

TL;DR: In vivo growth of IL-1-deficient tumor lines was evaluated in nu/nu mice and was compared with in vitro growth characteristics, finding that stronger tumorigenicity ofIL-1βcomp lines grows more aggressively, efficiently induce angiogenesis, and recruit inflammatory cells.