Margherita Rosati
National Institutes of Health
87 Papers
712 Citations
Margherita Rosati is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Immune system & DNA vaccination. The author has an hindex of 32, co-authored 76 publications.
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Papers
DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge.
Margherita Rosati,Cristina Bergamaschi,Antonio Valentin,Viraj Kulkarni,Rashmi Jalah,Candido Alicea,Vainav Patel,Agneta von Gegerfelt,David C. Montefiori,David Venzon,Amir S. Khan,Ruxandra Draghia-Akli,Koen K. A. Van Rompay,Barbara K. Felber,George N. Pavlakis +14 more
TL;DR: It is demonstrated that DNA vaccination in the absence of any heterologous boost can provide protection from high viremia comparable to any other vaccine modalities tested in this macaque model.
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SARS-CoV-2 antibody kinetics eight months from COVID-19 onset: Persistence of spike antibodies but loss of neutralizing antibodies in 24% of convalescent plasma donors.
Evangelos Terpos,Dimitris Stellas,Margherita Rosati,Theodoros N. Sergentanis,Xintao Hu,Marianna Politou,Vassiliki Pappa,Ioannis Ntanasis-Stathopoulos,Sevasti Karaliota,Jenifer Bear,Duncan Donohue,Maria Pagoni,Elisavet Grouzi,Eleni Korompoki,George N. Pavlakis,Barbara K. Felber,Meletios A. Dimopoulos +16 more
TL;DR: In this paper, the authors report the results of a follow-up evaluation of anti-SARS-CoV-2 antibodies in 148 convalescent plasma donors who participated in a phase 2 study at a median of 8.8-10.5 months (range 6.3 months) post first symptom onset.
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Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization
Vainav Patel,Antonio Valentin,Viraj Kulkarni,Margherita Rosati,Cristina Bergamaschi,Rashmi Jalah,Candido Alicea,Jacob T. Minang,Matthew T. Trivett,Claes Ohlen,Jun Zhao,Marjorie Robert-Guroff,Amir S. Khan,Ruxandra Draghia-Akli,Barbara K. Felber,George N. Pavlakis +15 more
TL;DR: The combination of optimized DNA vectors and improved intramuscular delivery by in vivo electroporation has the potential to elicit both cellular and humoral responses and dissemination to the periphery, and thus to improve DNA immunization efficacy.
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Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.
Amitinder Kaur,Hannah B. Sanford,Deirdre Garry,Sabine Lang,Sherry Klumpp,Daisuke Watanabe,Roderick T. Bronson,Jeffrey D. Lifson,Margherita Rosati,George N. Pavlakis,Barbara K. Felber,David M. Knipe,Ronald C. Desrosiers +12 more
TL;DR: The immunogenicity and protective capacity of replication-defective herpes simplex virus (HSV) vector-based vaccines were examined in rhesus macaques and support continued study of recombinant herpesviruses as a vaccine approach for AIDS.
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Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques
Viraj Kulkarni,Antonio Valentin,Margherita Rosati,Candido Alicea,Ashish K. Singh,Rashmi Jalah,Kate E. Broderick,Niranjan Y. Sardesai,Sylvie Le Gall,Beatriz Mothe,Christian Brander,Christian Brander,Morgane Rolland,James I. Mullins,George N. Pavlakis,Barbara K. Felber +15 more
TL;DR: Boosting CE-primed macaques with DNA expressing full-length p55gag increased both magnitude of CE responses and breadth of Gag immunity, demonstrating alteration of the hierarchy of epitope recognition in the presence of pre-existing CE-specific responses.