Margaret M. McDaniel
University of Texas Southwestern Medical Center
14 Papers
4 Citations
Margaret M. McDaniel is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 5, co-authored 10 publications. Previous affiliations of Margaret M. McDaniel include Cincinnati Children's Hospital Medical Center.
Chat about Author
Papers
TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation.
Ricardo A. Irizarry-Caro,Margaret M. McDaniel,Margaret M. McDaniel,Garrett R. Overcast,Garrett R. Overcast,Viral G. Jain,Ty D. Troutman,Chandrashekhar Pasare +7 more
TL;DR: The results reveal BCAP to be a critical cell-intrinsic switch that regulates transition of inflammatory macrophage to reparative macrophages by imprinting epigenetic changes.
253
T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity
Aakanksha Jain,Ricardo A. Irizarry-Caro,Ricardo A. Irizarry-Caro,Margaret M. McDaniel,Margaret M. McDaniel,Amanpreet Singh Chawla,Kaitlin R. Carroll,Garrett R. Overcast,Garrett R. Overcast,Naomi H. Philip,Andrew Oberst,Alexander V. Chervonsky,Jonathan D. Katz,Jonathan D. Katz,Chandrashekhar Pasare,Chandrashekhar Pasare +15 more
TL;DR: An inflammasome-independent, TNFR–Fas–caspase-8-dependent pathway of IL-1β production triggered by cognate interactions between effector CD4 + T cells and mononuclear phagocytes is described.
Severe Gut Microbiota Dysbiosis Is Associated With Poor Growth in Patients With Short Bowel Syndrome
Hannah G. Piper,Di Fan,Laura A. Coughlin,Evi X. Ho,Margaret M. McDaniel,Nandini Channabasappa,Jiwoong Kim,Min Kim,Xiaowei Zhan,Yang Xie,Andrew Y. Koh +10 more
TL;DR: Patients with SBS, particularly those with suboptimal growth, have a marked gut dysbiosis characterized by a paucity of beneficial commensal anaerobes, resulting in a deficiency of key metabolic enzymes found in the gut microbiomes of healthy children.
76
Quantifying Limits on Replication, Death, and Quiescence of Mycobacterium tuberculosis in Mice
TL;DR: The limits of the rates of bacterial replication, death, and quiescence during Mtb infection of mice were investigated and it was shown that to explain the data the majority of bacterial cells must be replicating in the chronic phase of infection further challenging widespread belief of nonreplicating Mtb in latency.
Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells
Margaret M. McDaniel,Amanpreet Singh Chawla,Aakanksha Jain,Hannah E. Meibers,Irene Saha,Yajing Gao,Viral V. Jain,Krishna M. Roskin,Sing Sing Way,Chandrashekhar Pasare +9 more
TL;DR: The results identify key pathways facilitating T cell cross-talk with innate immune cells and highlight potential therapeutic approaches for limiting myeloid-driven pathology resulting from dysregulated T cell activation.
18