In recent years, many new cortical areas have been identified in the macaque monkey. The number of identified connections between areas has increased even more dramatically. We report here on (1) a summary of the layout of cortical areas associated with vision and with other modalities, (2) a computerized database for storing and representing large amounts of information on connectivity patterns, and (3) the application of these data to the analysis of hierarchical organization of the cerebral cortex. Our analysis concentrates on the visual system, which includes 25 neocortical areas that are predominantly or exclusively visual in function, plus an additional 7 areas that we regard as visual-association areas on the basis of their extensive visual inputs. A total of 305 connections among these 32 visual and visual-association areas have been reported. This represents 31% of the possible number of pathways if each area were connected with all others. The actual degree of connectivity is likely to be closer to 40%. The great majority of pathways involve reciprocal connections between areas. There are also extensive connections with cortical areas outside the visual system proper, including the somatosensory cortex, as well as neocortical, transitional, and archicortical regions in the temporal and frontal lobes. In the somatosensory/motor system, there are 62 identified pathways linking 13 cortical areas, suggesting an overall connectivity of about 40%. Based on the laminar patterns of connections between areas, we propose a hierarchy of visual areas and of somatosensory/motor areas that is more comprehensive than those suggested in other recent studies. The current version of the visual hierarchy includes 10 levels of cortical processing. Altogether, it contains 14 levels if one includes the retina and lateral geniculate nucleus at the bottom as well as the entorhinal cortex and hippocampus at the top. Within this hierarchy, there are multiple, intertwined processing streams, which, at a low level, are related to the compartmental organization of areas V1 and V2 and, at a high level, are related to the distinction between processing centers in the temporal and parietal lobes. However, there are some pathways and relationships (about 10% of the total) whose descriptions do not fit cleanly into this hierarchical scheme for one reason or another. In most instances, though, it is unclear whether these represent genuine exceptions to a strict hierarchy rather than inaccuracies or uncertainities in the reported assignment.

/pdf/distributed-hierarchical-processing-in-the-primate-cerebral-1dvblm6d82.pdf

Distributed Hierarchical Processing in the Primate Cerebral Cortex

The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially fear conditioning. This work has pin- pointed the amygdala as an important component of the system involved in the acqui- sition, storage, and expression of fear memory and has elucidated in detail how stimuli enter, travel through, and exit the amygdala. Some progress has also been made in understanding the cellular and molecular mechanisms that underlie fear conditioning, and recent studies have also shown that the findings from experimental animals apply to the human brain. It is important to remember why this work on emotion succeeded where past efforts failed. It focused on a psychologically well-defined aspect of emo- tion, avoided vague and poorly defined concepts such as "affect," "hedonic tone," or "emotional feelings," and used a simple and straightforward experimental approach. With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior

http://gruberpeplab.com/3131/LeDoux_2000_Emotioncircuitbrain.pdf

Emotion Circuits in the Brain

The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially...

The contribution of the amygdala and hippocampus to the acquisition of conditioned fear responses to a cue (a tone paired with footshock) and to context (background stimuli continuously present in the apparatus in which tone-shock pairings occurred) was examined in rats. In unoperated controls, responses to the cue conditioned faster and were more resistant to extinction than were responses to contextual stimuli. Lesions of the amygdala interfered with the conditioning of fear responses to both the cue and the context, whereas lesions of the hippocampus interfered with conditioning to the context but not to the cue. The amygdala is thus involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli, whereas the hippocampus is only involved in fear conditioning situations involving complex, polymodal events. These findings suggest an associative role for the amygdala and a sensory relay role for the hippocampus in fear conditioning.

/pdf/differential-contribution-of-amygdala-and-hippocampus-to-4rauxwzsik.pdf

Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning

http://apps.usd.edu/coglab/schieber/pdf/mishkin_etal_1983.pdf

Object vision and spatial vision: two cortical pathways

As part of an attempt to understand how sensory stimuli influence emotional processes we examined all of the telencephalic sensory systems of the rhesus monkey for efferents to the amygdala and immediately surrounding structures, using primarily the Fink-Heimer technique. The results support the following conclusions.



1. All sensory systems contain areas that project to the amygdaloid complex (the somatosensory system, tentatively so), but not to more central limbic structures in the basal forebrain and hypothalamus. Consequently, whatever influence the sensory systems have on emotional processes mediated by these more central limbic structures is likely to depend largely on relays through the amygdala.



2. Except for the olfactory system, the amygdalopetal projections arise only from the later stages of cortical processing within each sensory system, i.e., from the modality-specific association areas one or more steps removed from the primary sensory areas. Thus, the modality-specific cortical sources of the amygdalopetal projections, like their amygdaloid targets, are important links in the sensory-limbic pathways. These sources are: for vision, areas TE and ventral TG; for audition, anterior TA and dorsal TG; for taste, area IA; and for somesthesis, possibly areas IA or IB. The amygdalopetal sources thus occupy a limited territory that begins dorsally in the anterior insula and extends ventrally across the anterior temporal neocortex as far as the rhinal fissure.



3. Within the visual system, progressively heavier and more widespread efferents arise from successively later stages of the amygdalopetal sources. The posterior half of TE sends a moderate projection to the dorsal part of the lateral nucleus, the anterior half of TE sends a heavy projection to the dorsal parts of both the lateral and basal nuclei, and the ventral part of TG sends a heavy projection to the dorsal and medial parts of the lateral and basal nuclei and to the dorsal part of the basal accessory nucleus. This pattern of progressive intensification and spread of the amygdalopetal projections applies also to the auditory system and probably to the other cortical sensory systems as well. The pattern suggests that a progressively greater influence on amygdaloid activity is exerted by successively more highly processed sensory information.



4. The efferents to the amygdaloid complex from the different sensory systems terminate in a dovetailed pattern. The major amygdaloid targets are: for vision, the anterodorsal parts of the lateral, basal, and basal accessory nuclei; for audition, the posterior parts of the lateral and basal accessory nuclei; for taste, the medial parts of the lateral and basal nuclei; and for olfaction, the cortical and medial nuclei. This pattern implies that each part of the amygdala is under the major influence of a particular sensory system.



5. The same cortical areas that give rise to separate sensory channels to the amygdala send efferents that converge upon the perirhinal and prorhinal cortices, areas known to be a major source of input to the hippocampus. Consequently, both the amygdala and hippocampus can be activated by the same highly processed sensory information, a conclusion that may help to account for a recent finding that these two structures can substitute for each other in a mechanism for recognition memory.

Organization of the amygdalopetal projections from modality-specific cortical association areas in the monkey

Projections of the nucleus and tracts of the stria terminalis following lesions at the level of the anterior commissure.

Consciousness and the disorders of consciousness can be more fully understood once they are integrated with the neurobiology of mental events. After a review of animal and human research, we found several anatomical structures in the central nervous system are required for consciousness. Identification of the critical structures, however, depends on what is meant by consciousness. In the general sense of mental responsivity, the reticular activating system must be intact. Consciousness has also been defined as the awareness of the sights, sounds, and feelings of everyday experience. In this sense, the system of sensory inputs and outputs of the anterior temporal cortex, amygdala, and the hippocampus must be functional. There is no neural evidence for “higher” consciousness.

Consciousness: a neurobiological approach.

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Organization of the amygdalopetal projections from modality-specific cortical association areas in the monkey

Projections of the nucleus and tracts of the stria terminalis following lesions at the level of the anterior commissure.

Consciousness: a neurobiological approach.