Margaret A. Baker
University of Pennsylvania
4 Papers
25 Citations
Margaret A. Baker is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: DNA damage & Chemistry. The author has an hindex of 3, co-authored 4 publications.
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Papers
Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples.
TL;DR: By combining the least complicated and expedient methods of sample handling with the sensitivity and specificity of the GSH assay by enzymatic recycling and the small volumes and software capabilities of microtiter plate technology, this work devised a rapid, sensitive, and easy assay for GSH and GSSG in biological samples.
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Diamide induced shift in protein and glutathione thiol: disulfide status delays DNA rejoining after X-irradiation of human cancer cells.
TL;DR: D diamide-induced protein thiol loss, and not GSH oxidation, is related to the cessation of DNA strand rejoining after X-irradiation, thereby affecting survival.
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Elaboration of cellular DNA breaks by hydroperoxides.
Margaret A. Baker,Shaoqin He +1 more
TL;DR: The overall results demonstrate the necessity for a metabolically active cell environment to elaborate maximal DNA strand breaks and cell death at hydroperoxide concentrations of 10(-4) or greater, but prevent strand break breaks and stimulate cell growth at 10(-5) M.