Mareike Schell
12 Papers
10 Citations
Mareike Schell is an academic researcher. The author has contributed to research in topics: Insulin resistance & Medicine. The author has an hindex of 5, co-authored 7 publications.
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Papers
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction
Sifan Chen,Sifan Chen,Ayana Henderson,Michael C. Petriello,Michael C. Petriello,Kymberleigh A. Romano,Mary E Gearing,Ji Miao,Mareike Schell,Walter J. Sandoval-Espinola,Jiahui Tao,Bingdong Sha,Mark J. Graham,Rosanne M. Crooke,André Kleinridders,Emily P. Balskus,Federico E. Rey,Andrew J. Morris,Andrew J. Morris,Sudha B. Biddinger +19 more
TL;DR: The endoplasmic reticulum stress kinase PERK (EIF2AK3) is revealed as a receptor for TMAO, and interventions to reduce T MAO can reduce PERK activation and FoxO1 levels in the liver, suggesting TmaO and PERK may be central to the pathogenesis of the metabolic syndrome.
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Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain.
Kristina Wardelmann,Sabine Blümel,Michaela Rath,Eugenia Alfine,Chantal Chudoba,Mareike Schell,Weikang Cai,Robert Hauffe,Kathrin Warnke,Tanina Flore,Katrin Ritter,Jürgen Weiß,C. Ronald Kahn,André Kleinridders +13 more
TL;DR: Insulin via ERK activation increases the expression of MSR genes in vitro as well as in the hypothalamus of streptozotocin-treated mice, and regulation propagates mitochondrial function by controlling mitochondrial proteostasis and preventing excessive autophagy under serum deprivation.
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GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
Robert Hauffe,Vanessa Stein,Chantal Chudoba,Tanina Flore,Michaela Rath,Katrin Ritter,Mareike Schell,Kristina Wardelmann,Stefanie Deubel,Johannes F. Kopp,Maria Luiza Schwarz,Kai Kappert,Matthias Blüher,Tanja Schwerdtle,Anna P. Kipp,André Kleinridders +15 more
TL;DR: GPx3 is identified as a novel regulator of IR expression and insulin sensitivity in adipose tissue and feeding mice a selenium-enriched high-fat diet alleviates diet-induced insulin resistance with increased insulin sensitivity, decreased tissue inflammation and elevated IR expression in WAT.
Brain imaging and neuropsychological assessment of individuals recovered from a mild to moderate SARS-CoV-2 infection
Marvin Petersen,Felix Naegele,Carola Mayer,Mareike Schell,Eric Petersen,Sally M. Kuehn,Juergen Gallinat,Jens Fiehler,Ofer Pasternak,Jakob Matschke,Markus Glatzel,Raphael Twerenbold,Christian Gerloff,Goetz Thomalla,B. Cheng +14 more
TL;DR: It is suggested that subtle changes in white matter extracellular water content may last beyond the acute infection with SARS-CoV-2, which was not associated with neuropsychological deficits, significant changes in cortical structure or vascular lesions several months after recovery.
Insulin modulates emotional behavior through a serotonin-dependent mechanism.
Hugo Martin,Sébastien Bullich,M. Martinat,Mathilde Chataigner,Mathieu Di Miceli,Vincent Simon,Samantha Clark,Jasmine Butler,Mareike Schell,Simran Chopra,Francis Chaouloff,André Kleinridders,Daniela Cota,Philippe De Deurwaerdère,Luc Pénicaud,Sophie Layé,Bruno P. Guiard,Xavier Fioramonti +17 more
TL;DR: In this paper , the authors show that insulin directly modulates the activity of dorsal raphe (DR) 5-HT neurons to dampen 5HT neurotransmission through a 5HT1A receptor-mediated inhibitory feedback.