Marcus Menger
Fraunhofer Society
22 Papers
145 Citations
Marcus Menger is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Aptamer & Chemistry. The author has an hindex of 12, co-authored 16 publications. Previous affiliations of Marcus Menger include Max Planck Society & Laboratory of Molecular Biology.
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Papers
Probing the SELEX Process with Next-Generation Sequencing
Tatjana Schütze,Barbara Wilhelm,Nicole Greiner,Hannsjörg Braun,Franziska Peter,Mario Mörl,Volker A. Erdmann,Hans Lehrach,Zoltán Konthur,Marcus Menger,Peter F. Arndt,Jörn Glökler +11 more
TL;DR: A new selection scheme is suggested that avoids a high number of iterative selection rounds while reducing time, PCR bias, and artifacts and high affinity aptamers can be readily identified simply by copy number enrichment in the first selection rounds.
Mg2+-dependent conformational changes in the hammerhead ribozyme
TL;DR: This approach provides a first set of data describing a Mg2+ binding topography to hammerhead RNA molecules and should be useful for the analysis of other RNA molecules.
112
A DNA aptamer with high affinity and specificity for therapeutic anthracyclines
Aniela Wochner,Marcus Menger,Dagmar Orgel,Birgit Cech,Martina Rimmele,Volker A. Erdmann,Jörn Glökler +6 more
TL;DR: The characterization of a DNA aptamer that displays high affinity and specificity for the anthracyclines daunomycin and doxorubicin, both of which are frequently used in chemotherapy, is described.
109
MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing.
Marcus Menger,Aysu Yarman,Júlia Erdőssy,Huseyin Bekir Yildiz,Róbert E. Gyurcsányi,Frieder W. Scheller,Frieder W. Scheller +6 more
TL;DR: The overall negative charge of the nucleotides makes aptamers prone to non-specific adsorption of positively charged constituents of the sample and the “biological” degradation of non-modified aptamer and ionic strength-dependent changes of conformation may be challenging in some application.
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An aptamer-based biosensor for detection of doxorubicin by electrochemical impedance spectroscopy.
TL;DR: With the advantages of high sensitivity, selectivity, and simple sensor construction, this method shows a high potential of impedimetric aptasensors in environmental monitoring.
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