Marcus Deichmann
5 Papers
Marcus Deichmann is an academic researcher. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 2, co-authored 2 publications.
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Papers
A Versatile in Vivo DNA Assembly Toolbox for Fungal Strain Engineering
Zofia Dorota Jarczynska,Katherina Garcia Vanegas,Marcus Deichmann,Christina Nørskov Jensen,M. J. Scheeper,Malgorzata E. Futyma,Tomas Strucko,Fabiano Jares Contesini,Tue Sparholt Jørgensen,Jakob Blæsbjerg Hoof,Uffe Hasbro Mortensen +10 more
TL;DR: A novel fungal in vivo DNA assembly toolbox for simple and flexible genetic engineering of filamentous fungi by determining the genetic- and sequence-length requirements and demonstrating that in nonhomologous end-joining deficient strains of Aspergillus nidulans, efficient fusions can be achieved by 25 bp sequence overlaps.
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Yeast-based screening platforms to understand and improve human health.
Marcus Deichmann,Frederik G. Hansson,Emil D. Jensen +2 more
TL;DR: This work highlights recent advances and opportunities of yeast-based technologies for cost-efficient chemical library screening on hGPCRs, accelerated deciphering of PPI networks with mating-based screening and selection, and accurate cell-cell communication with human immune cells.
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A yeast surface display platform for characterizing CAR T cell responses to cancer antigens
Marcus Deichmann,G. Schiesaro,Keerthana Ramanathan,Katrine Zeeberg,Nanna M. T. Koefoed,Maria Ormhøj,Rasmus U. W. Friis,Ryan T. Gill,Sine Reker Hadrup,Emil D. Jensen,Michael K. Jensen +10 more
TL;DR: Researchers developed a yeast-based platform, SCASA, to precisely regulate cancer antigen densities and control CAR T cell activation, enabling high-throughput characterization of CAR T cell functionality and potential applications in CAR T cell therapy.
Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts
Emil D. Jensen,Marcus Deichmann,Xin Ma,G. Schiesaro,Bettina Lengger,Justin M. Vento,Deniz Durmusoglu,Ibrahim S. Al’Abri,Jie Zhang,Nathan Crook,Michael Krogh Jensen +10 more
TL;DR: In this article , the pheromone-induced mating pathway in baker's yeast Saccharomyces cerevisiae has served as a model for studying heterologous GPCRs (hGPCRs).
Engineered yeast cells simulating CD19+ cancers to control CAR T cell activation
Marcus Deichmann,G. Schiesaro,Keerthana Ramanathan,Katrine Zeeberg,Nanna M. T. Koefoed,Maria Ormhøj,Rasmus U. W. Friis,Ryan T. Gill,Sine Reker Hadrup,Emil D. Jensen,Michael Krogh Jensen +10 more
TL;DR: The engineering of yeast is presented to robustly and dynamically modulate antigen densities, hence establishing a novel tool for assessing antigen-density thresholds in CAR T cell responses and ultimately support safer and better quality of personalized cancer therapies.