O exercicio agudo e um desafio a homeostase e apos exercicio fisico intenso ocorre transiente linfopenia e imunossupressao. As moleculas de adesaao celular sao expressas na superficie dos leucocitos e das celulas endoteliais, tendo um papel fundamental nas interacoes entre linfocito e endotelio. O objetivo do presente estudo foi analisar a expressao de CD73, CD90 e CD105 em leucocitos apos corrida de alta intensidade. Dez homens jovens foram inscritos em uma corrida de 4 km e o sangue foi coletado 60 minutos antes, 5 minutos, 1, 3, 6 e 24 hs apos a o exercicio, para avaliacao hematologica e determinacao de marcadores de superficie celulares por citometria de fluxo. Foi utilizado o teste ANOVA de uma via com o teste de Dunnet's como post hoc para a analise estatistica. Os dados foram considerados diferentes estatisticamente quando p<0,05. Os leucocitos aumentaram 30% e os granulocitos 40 -- 70% apos 6h de exercicio fisico. Linfopenia foi observada 1 h apos o exercicio, como esperado. Monocitos, eosinofilos e basofilos, e outros parâmetros hematologicos nao se alteraram. Linfocitos T, linfocitos T helper e celulas citotoxicas aumentaram em resposta ao exercicio. Linfocitos B e as celulas exterminadoras naturais (natural killers) aumentaram imediatamente apos o exercicio. A celulas CD73 + aumentaram somente imediatamente apos o exercicio e as celulas CD90 + diminuiram 24h apos o exercicio. Podemos concluir que a corrida de alta intensidade induziu a resposta classica do sistema imuno-endocrino e e capaz de alterar o numero de celulas CD73 + e CD90 + .

/pdf/exercicio-de-corrida-de-alta-intensidade-altera-a-expressao-1uxxoyu108.pdf

Exercício de corrida de alta intensidade altera a expressão de thy-1 e ectonucleotidase na superfície de linfócitos

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Exercício de corrida de alta intensidade altera a expressão de thy-1 e ectonucleotidase na superfície de linfócitos