Marcia J. Abbott
Chapman University
15 Papers
18 Citations
Marcia J. Abbott is an academic researcher from Chapman University. The author has contributed to research in topics: AMPK & Adipose tissue. The author has an hindex of 9, co-authored 15 publications. Previous affiliations of Marcia J. Abbott include University of California, Berkeley & Dana Corporation.
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Papers
Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
Maryam Ahmadian,Marcia J. Abbott,Tianyi Tang,Carolyn S.S. Hudak,Yangha Kim,Matthew D. Bruss,Marc K. Hellerstein,Hui-Young Lee,Varman T. Samuel,Gerald I. Shulman,Yuhui Wang,Robin E. Duncan,Chulho Kang,Hei Sook Sul +13 more
TL;DR: Overall, desnutrin is phosphorylated/activated by AMPK to increase lipolysis and brings FA oxidation and UCP-1 induction for thermogenesis and despite adiposity and impaired BAT function, desnutsrin-ASKO mice have improved hepatic insulin sensitivity with lower DAG levels.
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AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue.
TL;DR: Overall, for the first time, in vivo evidence of the role of AMPK in the phosphorylation and regulation of desnutrin/ATGL and HSL and thus adipose lipolysis is provided.
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Increased Bone Mass in Mice Lacking the Adipokine Apelin
Lalita Wattanachanya,W Lu,Ramendra K. Kundu,Liping Wang,Liping Wang,Marcia J. Abbott,Dylan O'Carroll,Thomas Quertermous,Robert A. Nissenson +8 more
TL;DR: The increased bone mass in mice lacking apelin suggested complex direct and paracrine/endocrine effects of apelin on bone, possibly via modulating insulin sensitivity, indicating that apelin functions as a physiologically significant antianabolic factor in bone in vivo.
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Phosphatidylinositol 3-kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 muscle cells: involvement of atypical protein kinase C-ζ in LCFA uptake but not oxidation
TL;DR: A direct effect of insulin is suggested on LCFA metabolism in muscle cells, and that downstream of PI3K, aPKC-zeta, but not PKB/Akt mediates the effects of insulin onLCFA uptake but not oxidation.
Contraction-induced signaling: evidence of convergent cascades in the regulation of muscle fatty acid metabolism.
TL;DR: This review addresses the roles played by 3 intracellular signaling cascades of interest in the regulation of fatty acid uptake and oxidation in contracting skeletal muscle; namely, the AMP-activated protein kinase (AMPK), calcium/calmodulin-dependent protein kinases (CaMKs), and the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling cascade.
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