Marcelo Simon Sola
Université Paris-Saclay
13 Papers
2 Citations
Marcelo Simon Sola is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Biology & Transgene. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Marcelo Simon Sola include University of Paris & French Institute of Health and Medical Research.
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Papers
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
Amine Meliani,Amine Meliani,Florence Boisgerault,Romain Hardet,Solenne Marmier,Fanny Collaud,Giuseppe Ronzitti,Christian Leborgne,Helena Costa Verdera,Helena Costa Verdera,Marcelo Simon Sola,Marcelo Simon Sola,Severine Charles,Alban Vignaud,Laetitia van Wittenberghe,Giorgia Manni,Olivier D. Christophe,Francesca Fallarino,Christopher J. Roy,Alicia M. Michaud,Petr Ilyinskii,Takashi Kei Kishimoto,Federico Mingozzi,Federico Mingozzi +23 more
TL;DR: It is demonstrated that synthetic vaccine particles encapsulating rapamycin (SVP[Rapa], co-administered with AAV vectors, prevents the induction of anti-capsid humoral and cell-mediated responses, enabling efficient AAV redosing in mice and nonhuman primates.
Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction.
Zachary Fitzpatrick,Christian Leborgne,Elena Barbon,Elisa Masat,Giuseppe Ronzitti,Laetitia van Wittenberghe,Alban Vignaud,Fanny Collaud,Severine Charles,Marcelo Simon Sola,Fabienne Jouen,Olivier Boyer,Federico Mingozzi +12 more
TL;DR: AAV8 vectors administered to mice passively immunized with anti-AAV8 BAbs showed a more efficient liver transduction and a unique vector biodistribution profile compared to mice immunizing with NAbs, highlighting a virtually opposite effect of neutralizing and binding antibodies on AAV vectors transduction.
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Enhanced liver gene transfer and evasion of preexisting humoral immunity with exosome-enveloped AAV vectors
Amine Meliani,Florence Boisgerault,Zachary Fitzpatrick,Solenne Marmier,Christian Leborgne,Fanny Collaud,Marcelo Simon Sola,Severine Charles,Giuseppe Ronzitti,Alban Vignaud,Laetitia van Wittenberghe,Béatrice Marolleau,Fabienne Jouen,Sisareuth Tan,Olivier Boyer,Olivier D. Christophe,Alain Brisson,Casey A. Maguire,Federico Mingozzi +18 more
TL;DR: The use of exosome-associated AAV (exo-AAV) vectors are described as a robust liver gene delivery system that allows the therapeutic vector dose to be decreased while protecting from preexisting humoral immunity to the capsid.
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AAV Gene Transfer with Tandem Promoter Design Prevents Anti-transgene Immunity and Provides Persistent Efficacy in Neonate Pompe Mice.
Pasqualina Colella,Pauline Sellier,Pauline Sellier,Helena Costa Verdera,Helena Costa Verdera,Francesco Puzzo,Laetitia van Wittenberghe,Nicolas Guerchet,Nathalie Daniele,Bernard Gjata,Solenne Marmier,Severine Charles,Marcelo Simon Sola,Isabella Ragone,Christian Leborgne,Fanny Collaud,Federico Mingozzi,Federico Mingozzi +17 more
TL;DR: The tandem promoter design overcomes important limitations of AAV-mediated gene transfer and can be beneficial when treating pediatric conditions requiring persistent multi-systemic transgene expression and prevention of anti-transgene immunity.
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A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome
Giuseppe Ronzitti,Giulia Bortolussi,Remco van Dijk,Fanny Collaud,Severine Charles,Christian Leborgne,Patrice Vidal,Samia Martin,Bernard Gjata,Marcelo Simon Sola,Laetitia van Wittenberghe,Alban Vignaud,Philippe Veron,Piter J. Bosma,Andrés F. Muro,Federico Mingozzi,Federico Mingozzi +16 more
TL;DR: The results indicate that transgene codon-optimization is a strategy that can improve efficacy of gene transfer but needs to be carefully tested in vitro and in vivo and support further translation of the approach to humans.
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