Marcela Mrhalova
Charles University in Prague
54 Papers
354 Citations
Marcela Mrhalova is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 15, co-authored 40 publications.
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Papers
•Journal Article
Epidermal growth factor receptor--its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinomas.
TL;DR: Criteria for cetuximab treatment in patients with HNSCC may differ from those already used for patients with colorectal carcinomas and should take different patterns of the EGFR protein overexpression into consideration.
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Kinetics of heme interaction with heme-binding proteins: the effect of heme aggregation state.
TL;DR: The kinetics of the interaction of heme with hemopexin and albumin was monitored by measuring the time dependence of changes in the Soret absorption spectra and revealed significant differences in the kinetic profiles (slowing down the binding interaction) that were dependent on the storage time of he me solutions at room temperature.
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Breast cancer: role of polymorphisms in biotransformation enzymes.
Jana Sarmanova,Simona Šůsová,Ivan Gut,Marcela Mrhalova,Roman Kodet,Jan Adamek,Zdeněk Roth,Pavel Soucek +7 more
TL;DR: The results suggest that genetic polymorphisms in biotransformation enzymes may play a significant role in the development of breast cancer.
57
Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas.
Miluse Hubackova,Radka Vaclavikova,Marie Ehrlichová,Marcela Mrhalova,Roman Kodet,Katerina Kubackova,David Vrána,Ivan Gut,Pavel Soucek +8 more
TL;DR: It is suggested that NQO2, SOD2 and SOD3 may significantly modify prognosis of breast cancer patients and that their significance should be further characterized.
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A novel quantitative PCR of proliferation markers (Ki-67, topoisomerase IIα, and TPX2): an immunohistochemical correlation, testing, and optimizing for mantle cell lymphoma
TL;DR: Real-time RT-PCR provides a novel approach applicable for clinical trials, and it represents a potent approach allowing to stratify MCL patients for entry into clinical trials according to the expression of the proliferation signature genes in their tumors.
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