Background Mounting studies have investigated impairments in social cognitive domains (including theory of mind [ToM] and facial emotion recognition [FER] in adult patients with temporal lobe epilepsy (TLE). However, to date, inconsistent findings remain. Methods A search of PubMed, Web of Science, and Embase databases was conducted until December 2021. Hedges g effect sizes were computed with a random-effects model. Meta-regressions were used to assess the potential confounding factors of between-study variability in effect sizes. Results The meta-analysis included 41 studies, with a combined sample of 1,749 adult patients with TLE and 1,324 healthy controls (HCs). Relative to HCs, adult patients with TLE showed large impairments in ToM (g = −0.92) and cognitive ToM (g = −0.92), followed by medium impairments in affective ToM (g = −0.79) and FER (g = −0.77). Besides, no (statistically) significant differences were observed between the magnitude of social cognition impairment in adult with TLE who underwent and those who did not undergo epilepsy surgery. Meta-regressions exhibited that greater severity of executive functioning was associated with more severe ToM defects, and older age was associated with more severe FER defects. Conclusions Results of this meta-analysis suggest that adult patients with TLE show differential impairments in the core aspects of social cognitive domains (including ToM and FER), which may help in planning individualized treatment with appropriate cognitive and behavioral interventions.

/pdf/theory-of-mind-and-facial-emotion-recognition-in-adults-with-2agkip7g.pdf

Theory of mind and facial emotion recognition in adults with temporal lobe epilepsy: A meta-analysis

Many studies have investigated impairments in two key domains of social cognition (theory of mind [ToM] and facial emotion recognition [FER]) in children and adolescents with epilepsy. However, inconsistent conclusions were found. Our objective was to characterize social cognition performance of children and adolescents with epilepsy. A literature search was conducted using Web of Science, PubMed, and Embase databases. The article retrieval, screening, quality assessment (Newcastle-Ottawa-Scale), and data extraction were performed independently by two investigators. A random-effects model was used to examine estimates. The meta-analysis included 19 studies, with a combined sample of 623 children and adolescents with epilepsy (mean [SD] age, 12.13 [2.62] years; 46.1% female) and 677 healthy controls [HCs]) (mean [SD] age, 11.48 [2.71] years; 50.7% female). The results revealed that relative to HCs, children and adolescents with epilepsy exhibited deficits in ToM (g = −1.08, 95% CI [−1.38, −0.78], p < 0.001, the number of studies [k] = 13), FER (g = −0.98, 95% CI [−1.33, −0.64], p < 0.001, k = 12), and ToM subcomponents (cognitive ToM: g = −1.04, 95% CI [−1.35, −0.72], p < 0.001, k = 12] and affective ToM: g = −0.73, 95% CI [−1.12, −0.34], p < 0.001, k = 8). In addition, there were no statistically significant differences in social cognition deficits between children and adolescents with focal epilepsy and generalized epilepsy. Meta-regressions confirmed the robustness of the results. These quantitative results further deepen our understanding of the two core domains of social cognition in children and adolescents with epilepsy and may assist in the development of cognitive interventions for this patient population. Systematic review registration: https://inplasy.com/inplasy-2022-3-0011/, identifier INPLASY202230011.

Social cognition in children and adolescents with epilepsy: A meta-analysis

Zusammenfassung Der vorliegende Artikel befasst sich mit Möglichkeiten der ambulanten psychotherapeutischen Arbeit bei Anfallserkrankungen. Er gibt Anregungen zur Bedeutung des Zeitrahmens in einer Behandlung, zur Vielfalt der Vorgehensmöglichkeiten, die sich aus einer ersten Exploration ergeben können, zur therapeutischen Relevanz der Fremdanamnese und zu den therapeutischen Möglichkeiten verschiedener psychotherapeutischer Ausrichtungen unter Berücksichtigung neuro- und sozialkognitiver Aspekte. 

Psychotherapeutic work with seizure patients in the outpatient setting: an integrative approach

Goal: This study aims to explore the temporal dynamics of functional connectivity in drug-resistant focal epilepsy, focusing on Temporal Lobe Epilepsy (TLE) and Extra-Temporal Lobe Epilepsy (ETLE), using magnetoencephalography (MEG). Methods: Temporal metrics such as Change Between States, Entropy of Transition Patterns, Entropy of Transition Probabilities, Dwell Time, Stability, and Max L1 Distance derived from dynamic functional connectivity matrices were analyzed across eight frequency bands (delta, theta, alpha, beta, low gamma, mid gamma, high gamma and broadband) in TLE and ETLE patients. Results: Significant differences were observed between TLE and ETLE. ETLE exhibited more widespread and unpredictable connectivity transitions, while TLE demonstrated localized and structured patterns. Entropy metrics indicated higher randomness in ETLE, and dwell time analysis revealed shorter state persistence in ETLE compared to TLE. Conclusions: The findings highlight the potential of MEG-based temporal connectivity metrics in characterizing network disruptions in focal epilepsy.

Temporal Dynamics of Functional Connectivity in Temporal and Extra-Temporal Lobe Epilepsy: A Magnetoencephalography-Based Study

The brain regions involved in social cognition and the regulation of social behavior form a widely distributed cortico-subcortical network. Therefore, many neurological disorders could affect social cognition and behavior. A persistent lack of valid tests and a rigid neuropsychological focus on language, attention, executive function, and memory have contributed to a long-standing neglect of social cognition in clinical diagnostics, although the DSM-5 recognizes it as one of the six core dimensions in neurocognitive disorders. To assess for the first time the diagnostic yield of a comprehensive social cognition battery (Networks of Emotion Processing [NEmo]), we administered several emotion recognition and theory of mind tests to three incidental clinical samples with different neurological conditions: temporal lobe epilepsy (n = 30), acquired brain injury (n = 24), Parkinson's disease (n = 19), and a healthy control group (n = 67). A multivariate analysis of covariance was performed to test the effect of group on subscales of the NEmo test battery, controlling for age and performance IQ. The results showed statistically significant differences between clinical groups and healthy controls. No differences were found for gender and lateralization of the predominant lesion side. In our incidental samples, 86% of individuals with temporal lobe epilepsy, 57% of individuals with acquired brain lesion, and 14% of individuals with Parkinson's disease underperformed on tests of social cognition compared with controls. These findings suggest a differential impact of neurological disorders on the risk of impaired social cognition and highlight the need to consider social cognition in diagnostics, counselling, therapy, and rehabilitation.

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pchj.650

A comparative study of social cognition in epilepsy, brain injury, and Parkinson's disease.

Abstract Background The aim of this review is to (a) characterize social cognition impairments in the domains of emotion recognition (ER) and theory of mind (ToM) in patients with epilepsy and (b) to review assessment tools with a focus on their validity and usability in clinical practice. Methods An electronic search for clinical studies investigating social cognition in epilepsy populations vs healthy control subjects (HC) yielded 53 studies for the meta-analysis and descriptive review. Results Results suggest that (1) social cognition is significantly impaired in patients with temporal lobe epilepsy (TLE), frontal lobe epilepsy (FLE) and patients with epilepsy not originating within the temporal or frontal lobes including idiopathic generalized epilepsies (eTLE/eFLE); (2) there is no significant difference between eTLE/eFLE and TLE regarding ER, while TLE and FLE patients perform worse than those with eTLE/eFLE, without significant differences between FLE and TLE regarding ToM ability. A descriptive analysis of the most commonly used assessment tools and stimulus material in this field revealed a lack of ecological validity, usability, and economic viability for everyday clinical practice. Conclusions Our meta-analysis shows that patients with epilepsy are at a significantly increased risk of deficits in social cognition. However, the underlying multifactorial mechanisms remain unclear. Future research should therefore specifically address the impairment of processing and methodological problems of testing. 

/pdf/toward-social-neuropsychology-of-epilepsy-a-meta-analysis-on-2eug1nqc.pdf

Toward social neuropsychology of epilepsy: a meta-analysis on social cognition in epilepsy phenotypes and a critical narrative review on assessment methods

Social neuropsychology of epilepsy in the digital age: A narrative review on challenges and opportunities

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A comparative study of social cognition in epilepsy, brain injury, and Parkinson's disease.

Toward social neuropsychology of epilepsy: a meta-analysis on social cognition in epilepsy phenotypes and a critical narrative review on assessment methods

Social neuropsychology of epilepsy in the digital age: A narrative review on challenges and opportunities