Marc Ruoß
University of Tübingen
14 Papers
15 Citations
Marc Ruoß is an academic researcher from University of Tübingen. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 7, co-authored 11 publications.
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Papers
Towards improved hepatocyte cultures: Progress and limitations.
Marc Ruoß,Massoud Vosough,Alfred Königsrainer,Silvio Nadalin,Silvia Wagner,Sahar Olsadat Sajadian,Diana Huber,Zahra Heydari,Sabrina Ehnert,Jan G. Hengstler,Andreas K. Nussler +10 more
TL;DR: There is an urgent need for reliable predictive in vitro tests, which unfailingly identify hepatotoxic drug candidates, reduce drug development time, expenses and the number of test animals.
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Hepatic Osteodystrophy-Molecular Mechanisms Proposed to Favor Its Development.
Sabrina Ehnert,Romina H. Aspera-Werz,Marc Ruoß,Steven Dooley,Jan G. Hengstler,Silvio Nadalin,Borna Relja,Andreas Badke,Andreas K. Nussler +8 more
TL;DR: In this paper, the authors summarize the molecular mechanisms favoring the development of hepatic osteodystrophy and compromising the healing of associated fractures, including alterations in vitamin D metabolism and action, disbalances in transforming growth factor beta (TGF-β) and bone morphogenetic protein (BMP) signaling with histone deacetylases (HDACs) as secondary regulators, as well as alterations in the receptor activator of nuclear factor kappa B ligand (RANKL)-osteoprotegerin (OPG) system mediated by sclerost
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A Standardized Collagen-Based Scaffold Improves Human Hepatocyte Shipment and Allows Metabolic Studies over 10 Days.
Marc Ruoß,Victor Häussling,Frank Schügner,Leon Olde Damink,Serene M. L. Lee,Liming Ge,Sabrina Ehnert,Andreas K. Nussler +7 more
TL;DR: The collagen-based scaffold allows the transport and cultivation of hepatocytes without loss of function over 10 days and it is demonstrated that significantly fewer cells were lost during transport.
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Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes.
Ensieh Zahmatkesh,Mohammad Hossein Ghanian,Ibrahim Zarkesh,Zahra Farzaneh,Majid Halvaei,Zahra Heydari,Zahra Heydari,Farideh Moeinvaziri,Farideh Moeinvaziri,Amnah Othman,Marc Ruoß,Abbas Piryaei,Roberto Gramignoli,Saeed Yakhkeshi,Andreas K. Nussler,Mustapha Najimi,Hossein Baharvand,Hossein Baharvand,Massoud Vosough +18 more
TL;DR: In this article, cell-sized microparticles (MPs) derived from liver extracellular matrix (ECM) were fabricated by chemical cross-linking of a water-in-oil dispersion of digested decellularized sheep liver.
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Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity
Marc Ruoß,Georg Damm,Massoud Vosough,Lisa Ehret,Carl Grom-Baumgarten,Martin Petkov,Silvio Naddalin,Ruth Ladurner,Daniel Seehofer,Andreas K. Nussler,Sahar Olsadat Sajadian +10 more
TL;DR: The study shows that certain phase I genes and their enzyme activities are increased by epigenetic modification in HepG2 cells with a concomitant reduction of EMT marker gene SNAIL, opening new opportunities for the usage of cell lines as a potential liver in vitro model for drug testing and development.
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