Marc K. Rosenblum
Memorial Sloan Kettering Cancer Center
305 Papers
2.3K Citations
Marc K. Rosenblum is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 73, co-authored 284 publications. Previous affiliations of Marc K. Rosenblum include Mount Sinai Hospital & University of Pennsylvania.
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Papers
Debio1347, an Oral FGFR Inhibitor: Results From a Single-Center Study in Pediatric Patients With Recurrent or Refractory FGFR-Altered Gliomas.
Sameer Farouk Sait,Sameer Farouk Sait,Stephen Gilheeney,Stephen Gilheeney,Tejus Bale,Sofia Haque,Marc Dinkin,Stephanie Vitolano,Marc K. Rosenblum,Katarzyna Ibanez,Daniel E. Prince,Krisoula Spatz,Ira J. Dunkel,Ira J. Dunkel,Matthias A. Karajannis,Matthias A. Karajannis +15 more
- 20 May 2021
Malignant transformation of a polymorphous low grade neuroepithelial tumor of the young (PLNTY).
Tejus Bale,Sameer Farouk Sait,Jamal Benhamida,Ryan Ptashkin,Sofia Haque,Liliana Villafania,Martin Sill,Justyna Sadowska,Razia B Akhtar,Benjamin Liechty,Rupa Juthani,Rupa Juthani,Marc Ladanyi,Mary Fowkes,Matthias A. Karajannis,Marc K. Rosenblum +15 more
TL;DR: A pediatric patient diagnosed with PLNTY with FGFR3-TACC3 fusion is presented, who experienced recurrent glioblastoma-like disease within < 18 months and was treated with focal proton radiotherapy with concurrent temozolomide without definitive disease recurrence at last follow up.
Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway
Melike Pekmezci,Meredith Stevers,Joanna J. Phillips,Joanna J. Phillips,Jessica Van Ziffle,Jessica Van Ziffle,Boris C. Bastian,Boris C. Bastian,Nadejda M. Tsankova,Bette K. Kleinschmidt-DeMasters,Marc K. Rosenblum,Tarik Tihan,Arie Perry,Arie Perry,David A. Solomon,David A. Solomon +15 more
TL;DR: Author(s): Pekmezci, Melike; Stevers, Meredith; Phillips, Joanna J; Van Ziffle, Jessica; Bastian, Boris C; Tsankova, Nadejda M; Kleinschmidt-DeMasters, Bette K; Rosenblum, Marc K; Tihan, Tarik; Perry, Arie; Solomon, David A
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
Andrey Korshunov,Dominik Sturm,Dominik Sturm,Marina Ryzhova,Volker Hovestadt,Marco Gessi,David T.W. Jones,Marc Remke,Paul A. Northcott,Arie Perry,Daniel Picard,Marc K. Rosenblum,Manila Antonelli,Eleonora Aronica,Ulrich Schüller,Martin Hasselblatt,Adelheid Woehrer,Olga Zheludkova,Ella Kumirova,Stéphanie Puget,Michael D. Taylor,Felice Giangaspero,V. Peter Collins,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Annie Huang,Torsten Pietsch,Stefan M. Pfister,Stefan M. Pfister,Marcel Kool +30 more
TL;DR: Recognition of this distinct pediatric brain tumor entity based on the fact that the three histological variants are molecularly and clinically uniform will help to distinguish ETMR from other embryonal CNS tumors and to better understand the biology of these highly aggressive and therapy-resistant pediatric CNS malignancies, possibly leading to alternate treatment strategies.
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
P. J. Cook,Rozario Thomas,Ramaraj Kannan,Esther Sanchez de Leon,Alexander Drilon,Marc K. Rosenblum,Maurizio Scaltriti,Robert Benezra,Andrea Ventura +8 more
TL;DR: This work demonstrates that BCAN-NTRK1 is a bona fide human glioma driver and describes a general strategy to define the oncogenic potential of novel gliomas-associated genomic rearrangements and to generate accurate preclinical models of this lethal human cancer.