Marc D. Ogan
University of California, San Francisco
9 Papers
121 Citations
Marc D. Ogan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gadolinium & Magnetic resonance imaging. The author has an hindex of 7, co-authored 9 publications.
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Papers
Albumin Labeled with Gd-DTPA: An Intravascular Contrast-Enhancing Agent for Magnetic Resonance Blood Pool Imaging: Preparation and Characterization
Marc D. Ogan,Udo P. Schmiedl,Michael E. Moseley,Wolfgang Grodd,Hannu Paajanen,Robert C. Brasch +5 more
TL;DR: A paramagnetic-labeled macromolecule, albumin-(Gd-DTPA), was prepared for use as an intravascular contrast agent for magnetic resonance imaging and covalently conjugated to human serum albumin through the bifunctional anhydride of DTPA.
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•Journal Article
Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool and perfusion imaging
TL;DR: The accumulated experimental results with albumin labeled with Gd-DTPA are described and the molar dose of the agent necessary for image enhancement is reduced, the proton relaxation effectiveness of such macromolecular agents is increased and they may even serve as markers of perfusion and abnormal vascular permeability.
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Comparison of initial biodistribution patterns of Gd-DTPA and albumin-(Gd-DTPA) using rapid spin echo MR imaging.
TL;DR: The initial biodistribution patterns of gadolinium-diethylenetria-minepentaacetic acid, an extracellular fluid contrast agent, and human serum albumin, used as an intravascular agent, were compared in the brain, heart, liver, and major mediastinal vessels of rats to support the notion that albumin-(Gd-DTPA) might be applied advantageously for the assessment of perfusion and blood-volume disorders.
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Magnetic resonance imaging of local soft tissue inflammation using gadolinium-DTPA.
TL;DR: Crageenan mucopolysaccharide-in-duced lesions provide a useful experimental model for in vivo evaluation of soft tissue inflammation using magnetic resonance imaging and no special benefit of paramagnetic contrast enhancement was demonstrated.
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Metabolic fate in the dog of the nitroxide moiety in a compound with potential utility as a contrast agent in MRI.
TL;DR: Nitroxides, paramagnetic compounds with demonstrated effectiveness as contrast agents in proton magnetic resonance imaging, shorten the relaxation times of protons and therefore cause an increase in image intensity in tissues into which they distribute, are examined in animals.
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