Marc B. Brown
Loughborough University
5 Papers
55 Citations
Marc B. Brown is an academic researcher from Loughborough University. The author has contributed to research in topics: Nile red & Fluorescence spectrometry. The author has an hindex of 4, co-authored 5 publications.
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Papers
An investigation of the use of Nile Red as a long-wavelength fluorescent probe for the study of α1-acid glycoprotein-drug interactions
TL;DR: Spectrofluorimetry in the long-wavelength region of the electromagnetic spectrum (600-1000 nm) is a fairly recent development in photoluminescence spectroscopy, which has numerous advantages over measurements in the more conventional ultraviolet and visible spectral region.
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Novel instrumentation and biomedical applications of very near infrared fluorescence.
TL;DR: A high wavelength fluorescent probe was added to four proteins, viz., bovine albumin, α1-acid glycoprotein, β-lactoglobulin and ovomucoid, showing that the binding site is less electrostatic and more hydrophobic in nature.
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Novel instrumentation and biomedical applications of very near-infrared fluorescence
Marc B. Brown,James N. Miller,D. P. Riley,Nichola J. Seare,Martin J. Bloxham,Steve J. Hill,Paul J. Worsfold,J. E. Manns,S. Hanks,J. E. Brown,J. A. Double +10 more
TL;DR: A high wavelength fluorescent probe was added to four proteins, viz., bovine albumin, alpha 1-acid glycoprotein, beta-lactoglobulin and ovomucoid, showing that the binding site is less electrostatic and more hydrophobic in nature.
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Use of Nile Red as a long-wavelength fluorophore in dual-probe studies of ligand-protein interactions.
TL;DR: The long-wavelength fluorescence probe, Nile Red, has polarity-dependent fluorescence intensity and wavelength properties that can be used to monitor the binding of drugs and other ligands to plasma proteins such as albumin and α-1 acid glycoprotein.
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Analytical Applications of Very Near-IR Fluorimetry
James N. Miller,Marc B. Brown,Nichola J. Seare,Stephen Summerfield +3 more
- 01 Jan 1993
TL;DR: The major advantages of fluorimetry in such fields are increased selectivity compared with UV-Visible absorption spectrometry, the great variety of sample handling methods available, and most of all the exceptional limits of detection accessible in favourable circumstances.
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