Maoping Tang
University of Rochester
12 Papers
24 Citations
Maoping Tang is an academic researcher from University of Rochester. The author has contributed to research in topics: BAG3 & Autophagy. The author has an hindex of 5, co-authored 9 publications. Previous affiliations of Maoping Tang include University of Rochester Medical Center.
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Papers
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes
TL;DR: It is demonstrated for the first time that BAG3 plays an important role in autophagic flux in the neurites of mature neurons through interaction with the post-synaptic cytoskeleton protein SYNPO (synaptopodin), providing evidence of a novel role for the co-chaperone BAG 3 in synapses.
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Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy
Bin Wang,Maoping Tang,Zi-Cheng Yuan,Zhongyu Li,Bin Hu,Xin Bai,Jin Xin Chu,Xiaoyang Xu,Xue-Qing Zhang +8 more
TL;DR: In this paper , the authors developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse model.
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Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner
TL;DR: Nrf2 regulation of autophagy-related genes likely plays a greater role in mediating the clearance of tau as an organism ages, and decreases in the autophagic genes were accompanied by significantly elevated levels of phospho-tau species in the 12-month-old Nrf2 (-/-) brains.
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mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy
TL;DR: In multiple female mouse models, it is shown that pyroptosis-triggering mRNA/LNPs turn cold tumors into hot ones and create a positive feedback loop to promote antitumor immunity, enhancing immunotherapy responses in immunologically cold tumors.
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Assessing the degradation of tau in primary neurons: The role of autophagy
TL;DR: Detailed methods for the preparation of neurons, immunoblotting and imaging analyses, genetic and pharmacological manipulation of autophagy with analyses, and methods to quantitatively measure changes in tau and phospho-tau levels are presented.
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