Maofu Fu
Thomas Jefferson University
48 Papers
890 Citations
Maofu Fu is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Cyclin D1 & Cyclin D. The author has an hindex of 40, co-authored 48 publications. Previous affiliations of Maofu Fu include Albert Einstein College of Medicine & Georgetown University Medical Center.
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Papers
Minireview: Cyclin D1: normal and abnormal functions.
TL;DR: Accumulating evidence suggests that in addition to its original description as a CDK-dependent regulator of the cell cycle, cyclin D1 also conveys cell cycle orCDK-independent functions.
1K
Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.
Richard T. Lee,Chris Albanese,Maofu Fu,Mark D'Amico,Bing Lin,Genichi Watanabe,G K Haines,Peter M. Siegel,Mien Chie Hung,Yosef Yarden,Jonathan M. Horowitz,William J. Muller,Richard G. Pestell +12 more
TL;DR: It is demonstrated that E2F-1 mediates a Neu-signaling cascade tocyclin D1 and identify cyclin D 1 as a critical downstream target of neu-induced transformation.
378
Direct Acetylation of the Estrogen Receptor α Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity
Chenguang Wang,Maofu Fu,Ruth Hogue Angeletti,Linda Siconolfi-Baez,Anne T. Reutens,Chris Albanese,Michael P. Lisanti,Benita S. Katzenellenbogen,Shigeaki Kato,Torsten A. Hopp,Suzanne A. W. Fuqua,Gabriela N. Lopez,Peter J. Kushner,Richard G. Pestell +13 more
TL;DR: It is shown that the estrogen receptor (ERα) is acetylated in vivo, and the conservation of the ERα acetylation motif in a phylogenetic subset of nuclear receptors suggests that direct acetylators may contribute to additional signaling pathways involved in metabolism and development.
372
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Toula Bouras,Maofu Fu,Anthony A. Sauve,Fang Wang,Andrew A. Quong,Neil D. Perkins,Ronald T. Hay,Wei Gu,Richard G. Pestell +8 more
TL;DR: The p300 protein serves as a rate-limiting transcriptional cointegrator of diverse transcription factors either to activate or to repress transcription through modular subdomains and may serve an important integration point during metabolism and cellular differentiation.
366
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
Mark D'Amico,James Hulit,Derek F. Amanatullah,Brian T. Zafonte,Chris Albanese,Boumediene Bouzahzah,Maofu Fu,Leonard H. Augenlicht,Lawrence A. Donehower,Ken-Ichi Takemaru,Randall T. Moon,R J Davis,Michael P. Lisanti,Michael Shtutman,Jacob Zhurinsky,Avri Ben-Ze'ev,Armelle A. Troussard,Shoukat Dedhar,Richard G. Pestell +18 more
TL;DR: It is concluded that the cyclin D1 gene is regulated by the Wnt-1 and ILK signaling pathways and that ILK induction of cycl in D1 involves the CREB signaling pathway in mammary epithelial cells.
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