The invention relates to substituted pyrimidine compounds and an application thereof. The substituted pyrimidine compounds are compounds shown in a formula I (the specific structure is shown in the specification or claims), stereoisomers of the compounds or pharmaceutically acceptable salts of the compounds. An in-vitro activity test proves that the substituted pyrimidine compounds have cholinesterase inhibiting activity, metal ion chelation, inhibition of generation of metal ion induced free radicals, inhibition of metal ion induced Abeta aggregation and the like. Therefore, the substituted pyrimidine compounds are expected to be used for preparing Alzheimer's disease treating and/or preventing drugs.

Substituted pyrimidine compounds and application thereof

The invention relates to a multi-target active compound and application thereof. The multi-target active compound is a compound shown as a formula I or a pharmaceutically acceptable salt thereof. Themulti-target active compound provided by the invention has a RAGE inhibitory activity, a 5-HT1A agonistic activity and a 5-HT reuptake inhibitory activity at the same time, and is expected to be developed into a drug with a multi-target function and for treating, improving and/or preventing complicated depressive Alzheimer's disease. In the formula I, X is carbon or nitrogen, and R is C1-C4 alkyl.

Multi-target active compound and application thereof

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Substituted pyrimidine compounds and application thereof

Multi-target active compound and application thereof