13 Papers
110 Citations
Manyu Li is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Adrenomedullin & Receptor. The author has an hindex of 10, co-authored 13 publications.
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Papers
Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia.
Feng Li,Tomofumi Fushima,Gen Oyanagi,H. W. Davin Townley-Tilson,Emiko Sato,Hironobu Nakada,Yuji Oe,John R. Hagaman,Jennifer Wilder,Manyu Li,Akiyo Sekimoto,Daisuke Saigusa,Hiroshi Sato,Sadayoshi Ito,J. Charles Jennette,Nobuyo Maeda,S. Ananth Karumanchi,Oliver Smithies,Nobuyuki Takahashi +18 more
TL;DR: Dietary nicotinamide, a nonteratogenic amide of vitamin B3, improves the maternal condition, prolongs pregnancies, and prevents FGR in two contrasting mouse models of PE, and is shown to benefit both dams and pups.
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Haploinsufficiency for Adrenomedullin Reduces Pinopodes and Diminishes Uterine Receptivity in Mice
TL;DR: It is demonstrated that Adm+/− female mice displayed reduced pregnancy success rates that were not caused by defects in folliculogenesis, ovulation, or fertilization and a new class of pharmacologically tractable proteins that are involved in establishing uterine receptivity through the regulation of pinopode formation are identified.
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Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis
TL;DR: It is demonstrated that AM derived from the epicardium, but not the myocardium or cardiac fibroblast, is responsible for driving cardiomyocyte hyperplasia, thus representing a novel and clinically relevant factor potentially related to mechanisms of cardiac repair after injury.
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Cohort of estrogen-induced microRNAs regulate adrenomedullin expression
TL;DR: It is revealed that heart function is enhanced in Adm(hi/hi) females, which along with Adm expression levels, was reversed following ovariectomization, and it was revealed that estrogen-induced microRNAs are important for balancing cardiac Admexpression in females.
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Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy.
Daniel O. Kechele,William P. Dunworth,Claire E. Trincot,Sarah E. Wetzel-Strong,Manyu Li,Hong Ma,Jiandong Liu,Kathleen M. Caron +7 more
TL;DR: Data suggest a functional requirement for RAMP2 in the modulation of additional G-protein–coupled receptor pathways in vivo, which is critical for sustained cardiovascular homeostasis and extends beyond the endothelium and canonical adrenomedullin/calcitonin receptor-like receptor signaling.
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