Manuela Volta
King's College London
8 Papers
135 Citations
Manuela Volta is an academic researcher from King's College London. The author has contributed to research in topics: Neurofibromin 1 & DNA methylation. The author has an hindex of 7, co-authored 8 publications.
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Papers
A data-driven approach to preprocessing Illumina 450K methylation array data
Ruth Pidsley,Chloe C. Y. Wong,Manuela Volta,Katie Lunnon,Jonathan Mill,Jonathan Mill,Leonard C. Schalkwyk +6 more
TL;DR: It is demonstrated that quantile normalization methods produce marked improvement, even in highly consistent data, by all three metrics, and that careful selection of preprocessing steps can minimize variance and thus improve statistical power, especially for the detection of the small absolute DNA methylation changes likely associated with complex disease phenotypes.
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Katie Lunnon,Rebecca G. Smith,Eilis Hannon,Philip L. De Jager,Gyan Srivastava,Manuela Volta,Claire Troakes,Safa Al-Sarraj,Joe Burrage,Ruby Macdonald,Daniel Condliffe,Lorna W. Harries,Pavel Katsel,Vahram Haroutunian,Zachary Kaminsky,C Joachim,John Powell,Simon Lovestone,David A. Bennett,Leonard C. Schalkwyk,Jonathan Mill +20 more
TL;DR: This study represents, to the best of the knowledge, the first epigenome-wide association study of AD employing a sequential replication design across multiple tissues and highlights the power of this approach for identifying methylomic variation associated with complex disease.
Bipartite Interaction between Neurofibromatosis Type I Protein (Neurofibromin) and Syndecan Transmembrane Heparan Sulfate Proteoglycans
TL;DR: It is suggested that interaction with different members of the syndecan family may be a mechanism for localizing neurofibromin to specialized domains of the plasma membrane.
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Tissue-specific patterns of allelically-skewed DNA methylation
Sarah J. Marzi,Emma L. Meaburn,Emma Dempster,Katie Lunnon,Jose L. Paya-Cano,Rebecca G. Smith,Manuela Volta,Claire Troakes,Leonard C. Schalkwyk,Jonathan Mill +9 more
TL;DR: It is shown that ASM sites are enriched in DNase I hypersensitivity sites and often located in an extended genomic context of intermediate DNA methylation, which contributes to the understanding of the nature of differential DNAmethylation across tissues and have important implications for genetic studies of complex disease.
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Characterisation of the interaction between syndecan-2, neurofibromin and CASK: dependence of interaction on syndecan dimerization.
TL;DR: A phylogenetic study of syndecan sequences finds correspondence between conserved residues and mutations affecting both dimerization and interactions; it is found that fish have a very different Syndecan repertoire from tetrapods and that the multiple neurofibromin regions bind competitively, rather than co-operatively, to syndecans.
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