Manuela Pardini
Istituto Superiore di Sanità
54 Papers
392 Citations
Manuela Pardini is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 24, co-authored 54 publications. Previous affiliations of Manuela Pardini include University of Pisa.
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Papers
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
Alessandra Romagnoli,Marilena P. Etna,Elena Giacomini,Manuela Pardini,Maria Elena Remoli,Marco Corazzari,Laura Falasca,Delia Goletti,Valérie Gafa,Roxane Simeone,Giovanni Delogu,Mauro Piacentini,Roland Brosch,Gian Maria Fimia,Eliana M. Coccia +14 more
TL;DR: It is demonstrated that Mtb alters the autophagic machinery through the ESX-1 system, and thereby opens new exciting perspectives to better understand the relationship between Mtb virulence and its ability to escape the DC-mediated immune response.
258
Mycobacterium tuberculosis -induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells
Marilena P. Etna,Alessandro Sinigaglia,Angela Grassi,Elena Giacomini,Alessandra Romagnoli,Manuela Pardini,Martina Severa,Melania Cruciani,Fabiana Rizzo,Eleni Anastasiadou,Barbara Di Camillo,Luisa Barzon,Gian Maria Fimia,Riccardo Manganelli,Eliana M. Coccia +14 more
TL;DR: How Mtb can manipulate cellular miRNA expression to regulate Atg3 for its own survival is suggested, and the importance to develop novel therapeutic strategies against tuberculosis that would boost autophagy is highlighted.
Cell wall-associated alpha-glucan is instrumental for Mycobacterium tuberculosis to block CD1 molecule expression and disable the function of dendritic cell derived from infected monocyte.
Maria Cristina Gagliardi,Anne Lemassu,Raffaela Teloni,Sabrina Mariotti,Valeria Sargentini,Manuela Pardini,Mamadou Daffé,Roberto Nisini +7 more
TL;DR: A mechanism of Mtb–monocyte interaction mediated by CW‐associated alpha‐glucan is proposed, which allows the bacterium to evade both innate and acquired immune responses.
91
The Mycobacterium tuberculosis Sigma Factor σB Is Required for Full Response to Cell Envelope Stress and Hypoxia In Vitro, but It Is Dispensable for In Vivo Growth
P. A. Fontán,Martin I. Voskuil,Martin I. Voskuil,Manuel Gómez,Dejiang Tan,Manuela Pardini,Riccardo Manganelli,Lanfranco Fattorini,Gary K. Schoolnik,Issar Smith +9 more
TL;DR: The M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia was especially defective in survival under hypoxic conditions in vitro, but it was not attenuated for growth in THP-1 cells or during mouse and guinea pig infection.
82
Human CD56bright and CD56dim natural killer cell subsets respond differentially to direct stimulation with Mycobacterium bovis bacillus Calmette-Guérin.
Giovanna Batoni,Semih Esin,Flavia Favilli,Manuela Pardini,Daria Bottai,Giuseppantonio Maisetta,Walter Florio,Mario Campa +7 more
TL;DR: It is demonstrated that CD56bright and CD56dim human NK‐cell subsets exert different functional activities in response to a live bacterial pathogen.
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