Manuela Nigro
10 Papers
Manuela Nigro is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 7 publications.
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Papers
Microglia and Alzheimer’s Disease
TL;DR: It is imperative to comprehend the intricate mechanisms that result in microglial impairment to develop new immunomodulating therapies that primarily attempt to recover the physiological role of microglia, allowing them to carry out their core function of brain protection.
Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease
Paola Tedeschi,Manuela Nigro,Alessia Travagli,Martina Catani,Alberto Cavazzini,Stefania Merighi,Stefania Gessi +6 more
TL;DR: The chemical composition, metabolism and bioavailability of garlic bioactive compounds are reviewed and an overview of signaling mechanisms triggered by garlic derivatives are provided, with a focus on allicin and AGE, to improve learning and memory.
Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer’s Disease
Stefania Merighi,Pier Andrea Borea,Katia Varani,Fabrizio Vincenzi,Alessia Travagli,Manuela Nigro,Silvia Pasquini,R. Rama Suresh,Sung-Won Kim,Nora D. Volkow,Kenneth A. Jacobson,Stefania Gessi +11 more
TL;DR: In vitro and in vivo studies have demonstrated that A2A adenosine receptor antagonists may counteract each of these clinical signs of Alzheimer's disease, representing an important new strategy to fight a disease for which unfortunately only symptomatic drugs are available.
Pharmacology of Adenosine Receptors: Recent Advancements
Fabrizio Vincenzi,Silvia Pasquini,Chiara Contri,Martina Cappello,Manuela Nigro,Alessia Travagli,Stefania Merighi,Stefania Gessi,Pier Andrea Borea,Katia Varani +9 more
TL;DR: The latest studies discussed herein shed light on novel mechanisms through which ARs exert control over pathophysiological states, and introduce new ligands and innovative strategies for receptor activation, presenting compelling evidence of efficacy along with the implicated signaling pathways.
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The Effect of Different Storage Conditions on Phytochemical Composition, Shelf-Life, and Bioactive Compounds of Voghiera Garlic PDO
Paola Tedeschi,Federica Brugnoli,Stefania Merighi,Silvia Grassilli,Manuela Nigro,Martina Catani,Stefania Gessi,Valeria Bertagnolo,Alessia Travagli,Maria Fiorenza Caboni,Alberto Cavazzini +10 more
TL;DR: In this article , the effect of storage on the phytochemical composition, biological effects, and shelf-life of Voghiera garlic PDO was examined, taking into account the high importance of organosulfur and phenolic compounds for the bioactive potency of garlic and its shelf life.