Manuela Minto
Mario Negri Institute for Pharmacological Research
5 Papers
49 Citations
Manuela Minto is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Manuela Minto include University of Milan.
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Papers
Role of clusterin in cell adhesion during early phases of programmed cell death in P19 embryonic carcinoma cells.
TL;DR: It is suggested that clusterin expression may partially control cell adhesion with no influence on apoptosis in P19 cells, under defined conditions.
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•Journal Article
Chlorpromazine inhibits tumour necrosis factor synthesis and cytotoxicity in vitro.
Mirella Zinetti,Grazia Galli,M. T. Demitri,Giamila Fantuzzi,Manuela Minto,Pietro Ghezzi,R. Alzani,Elena Cozzi,Maddalena Fratelli +8 more
TL;DR: The data suggest that CPZ reduced cytotoxicity by inhibiting some steps in the TNF-alpha signalling pathways, which could explain the overall protection.
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Inhibition of Nuclear Factor-κB by a Nitro-Derivative of Flurbiprofen: A Possible Mechanism for Antiinflammatory and Antiproliferative Effect
Maddalena Fratelli,Manuela Minto,Andrea Crespi,Eugenio Erba,Peter Vandenabeele,Piero Del Soldato,Pietro Ghezzi +6 more
TL;DR: Flurbiprofen nitroxybutyl ester inhibits nuclear factor- kappaB (NF-kappaB) activity and cell growth in L929 cells at a concentration of 100 microM, whereas flurbip rofen is inactive.
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Regional production of nitric oxide after a peripheral or central low dose of LPS in mice.
Mirella Zinetti,Fabio Benigni,Silvano Sacco,Manuela Minto,Grazia Galli,Sarah Salmona,Giuseppe Andreoni,Annamaria Vezzani,Pietro Ghezzi,Maddalena Fratelli +9 more
TL;DR: A cross-talk between periphery and brain in the regulation of NO by LPS is demonstrated and the possibility of iNOS-independent NO synthesis stimulated by L PS is implied by the discrepancy between the amount of local NO production suggested by ADP ribosylation and the iNos mRNA levels.
7
Mycobacterial Cpn10 promotes recognition of the mammalian homologue by a mycobacterium-specific antiserum.
Manuela Minto,Grazia Galli,Elisabetta Gianazza,Ivano Eberini,Giuseppe Legname,Gianluca Fossati,Daniela Modena,Fabrizio Marcucci,Paolo Mascagni,Pietro Ghezzi,Maddalena Fratelli +10 more
TL;DR: Evidence is given for a peculiar behavior of an antiserum against Mycobacterium tuberculosis chaperonin 10 (m-Cpn10), which could have implications for the mechanism of self-recognition by antibodies against non-self, and could imply a breaking ofSelf-tolerance in situations of infection or vaccination.
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