Manuela Ecker
University of New South Wales
8 Papers
Manuela Ecker is an academic researcher from University of New South Wales. The author has contributed to research in topics: Chemistry & T-cell receptor. The author has an hindex of 3, co-authored 4 publications.
Chat about Author
Papers
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.
Ewoud B. Compeer,Ewoud B. Compeer,Felix Kraus,Felix Kraus,Manuela Ecker,Gregory M. I. Redpath,Mayan Amiezer,Mayan Amiezer,Nils Rother,Nils Rother,Philip R. Nicovich,Natasha Kapoor-Kaushik,Qiji Deng,Guerric P. B. Samson,Zhengmin Yang,Jieqiong Lou,Michael Carnell,Haig Vartoukian,Katharina Gaus,Jérémie Rossy,Jérémie Rossy +20 more
TL;DR: It is shown that a mobile endocytic network connects clathrin-independent receptor endocytosis to recycling which is required for T cell activation, and that flotillins are essential for Tcell activation, supporting TCR nanoscale organization and signaling.
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation
Ewoud B. Compeer,Felix Kraus,Manuela Ecker,G. Redpath,Mayan Amiezer,Nils Rother,Philip R. Nicovich,Natasha Kapoor-Kaushik,Qiji Deng,Guerric Samson,Zhongmin Yang,Jieqiong Lou,Michael Carnell,Haig Vartoukian,Katharina Gaus,Jérémie Rossy +15 more
TL;DR: It is shown that a mobile endocytic network connects clathrin-independent receptor endocytosis to recycling which is required for T cell activation, and that flotillins are essential for T cell activation, supporting TCR nanoscale organization and signaling.
45
Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis.
Gregory M. I. Redpath,Manuela Ecker,Natasha Kapoor-Kaushik,Haig Vartoukian,Michael Carnell,Daryan Kempe,Maté Biro,Nicholas Ariotti,Jérémie Rossy,Jérémie Rossy +9 more
TL;DR: It is shown that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive endosomes to support its rapid recycling.
Quantitative visualization of endocytic trafficking through photoactivation of fluorescent proteins.
TL;DR: In this article, a toolset based on photoactivation of fluorescence was presented for endocytic trafficking control the density of molecules at the plasma membrane which determines how cells interact with their environment.
8