Manuela Bechtel
University of Cologne
5 Papers
16 Citations
Manuela Bechtel is an academic researcher from University of Cologne. The author has contributed to research in topics: Nidogen-2 & Laminin. The author has an hindex of 5, co-authored 5 publications.
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Papers
Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier
Susan D. John,Lars Thiebach,Christian Frie,Sharada Mokkapati,Manuela Bechtel,Roswitha Nischt,Sally Rosser-Davies,Mats Paulsson,Neil Smyth,Neil Smyth +9 more
TL;DR: While TGase 3 is of unique functional importance in hair, in the epidermis loss ofTGase 3 can be compensated for by other family members.
Impaired wound healing in mice lacking the basement membrane protein nidogen 1.
Anke Baranowsky,Sharada Mokkapati,Manuela Bechtel,Jenny Krügel,Nicolai Miosge,Claudia Wickenhauser,Neil Smyth,Roswitha Nischt +7 more
TL;DR: Differences between control and mutant wounds at day 10 post wounding did not affect the ultrastructural appearance of the dermo-epidermal BM suggesting a non-structural role for nidogen 1 in wound repair.
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Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin γ1 chain
Sharada Mokkapati,Anja Fleger-Weckmann,Manuela Bechtel,Manuel Koch,Dirk Breitkreutz,Ulrike Mayer,Neil Smyth,Roswitha Nischt +7 more
TL;DR: It is demonstrated that in vivo only nidogen 1 deposition is critically dependent on the nidogenic binding modules of the laminin γ1 and γ3 chains, whereasnidogen 2 is independently recruited either by binding to an alternative site on laminIn or to other BM proteins.
17
Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures
Manuela Bechtel,Manuel V. Keller,Wilhelm Bloch,Takako Sasaki,Petra Boukamp,Frank Zaucke,Mats Paulsson,Roswitha Nischt +7 more
TL;DR: This finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions, thus providing an explanation for the phenotypical differences observed between nidogen‐1 and ‐2 deficient mice.
Absence of the Basement Membrane Component Nidogen 2, but not of Nidogen 1, Results in Increased Lung Metastasis in Mice.
TL;DR: Results suggest that absence of nidogen 2 might result in subtle changes of endothelial BMs in the lung, which would allow faster passage of tumor cells through these BMs, leading to a higher metastasis rate and more larger tumors.