Manuel Estrada
University of Chile
39 Papers
370 Citations
Manuel Estrada is an academic researcher from University of Chile. The author has contributed to research in topics: Signal transduction & Myocyte. The author has an hindex of 23, co-authored 38 publications. Previous affiliations of Manuel Estrada include Marine Biological Laboratory & Yale University.
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Papers
Testosterone Stimulates Intracellular Calcium Release and Mitogen-Activated Protein Kinases Via a G Protein- Coupled Receptor in Skeletal Muscle Cells
TL;DR: Results are consistent with a fast effect of testosterone, involving a G protein-linked receptor at the plasma membrane, IP(3)-mediated Ca(2+) signal, and the Ras/MEK/ERK pathway in muscle cells.
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Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2
TL;DR: It is shown that PC2 coimmunoprecipitates with the cardiac ryanodine receptor (RyR2) from mouse heart and that loss of this regulation of RyR2, as occurs when PC2 is mutated, results in altered Ca2+ signaling in the heart.
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes.
Jose Miguel Vicencio,Cristian Ibarra,Manuel Estrada,Mario Chiong,Dagoberto Soto,Valentina Parra,Guillermo Díaz-Araya,Enrique Jaimovich,Sergio Lavandero +8 more
TL;DR: The mechanism for the rapid, testosterone-induced increase in intracellular Ca2+ is through activation of a plasma membrane receptor associated with a Pertussis toxin-sensitive G protein-phospholipase C/inositol 1,4,5-trisphosphate signaling pathway.
155
Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy.
Carla Basualto-Alarcón,Gonzalo Jorquera,Francisco Altamirano,Enrique Jaimovich,Manuel Estrada +4 more
TL;DR: A crosstalk between pathways involving fast intracellular signaling and the AR to explain testosterone-induced skeletal muscle hypertrophy is suggested.
129
Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses.
Allan White,Manuel Estrada,Katherine Walker,Pamela Wisnia,Gonzalo Filgueira,Fernando Valdés,Oscar F. Araneda,Claus Behn,Ramón Martínez +8 more
TL;DR: The results would suggest that the administration of ascorbate could nullify the oxidative stress produced by exercise in thoroughbred racehorses, but could not prevent muscular damage.
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