Manuel E. Engelhorn
Memorial Sloan Kettering Cancer Center
18 Papers
268 Citations
Manuel E. Engelhorn is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 13, co-authored 18 publications. Previous affiliations of Manuel E. Engelhorn include Cornell University.
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Papers
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells.
TL;DR: Results show that regulatory T cells are the major regulators of concomitant tumor immunity against this weakly immunogenic tumor.
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A Single Heteroclitic Epitope Determines Cancer Immunity After Xenogeneic DNA Immunization Against a Tumor Differentiation Antigen
Jason S. Gold,Cristina R. Ferrone,José A. Guevara-Patiño,William G. Hawkins,Ruben Dyall,Manuel E. Engelhorn,Jedd D. Wolchok,Jedd D. Wolchok,Jonathan J. Lewis,Jonathan J. Lewis,Alan N. Houghton,Alan N. Houghton +11 more
TL;DR: In this model of xenogeneic DNA immunization, the presence of an hgp100 heteroclitic epitope with a higher affinity for MHC created by three amino acid substitutions at predicted minor anchor residues was necessary and sufficient to induce protective tumor immunity in H-2b mice with melanoma.
Optimization of a self antigen for presentation of multiple epitopes in cancer immunity
José A. Guevara-Patiño,Manuel E. Engelhorn,Mary Jo Turk,Cailian Liu,Fei Duan,Gabrielle Rizzuto,Adam D. Cohen,Taha Merghoub,Jedd D. Wolchok,Alan N. Houghton +9 more
TL;DR: These studies demonstrate how rationally designed DNA vaccines directed against self antigens for enhanced antigen processing and presentation reveal novel self epitopes and elicit multi-specific T cell responses to nonimmunogenic, nonmutated self antIGens, enhancing immunity against cancer self antigelens.
•Journal Article
Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects.
Wilbur B. Bowne,Jedd D. Wolchok,William G. Hawkins,Roopa Srinivasan,Polly D. Gregor,Nathalie E. Blachere,Yoichi Moroi,Manuel E. Engelhorn,Alan N. Houghton,Jonathan J. Lewis +9 more
TL;DR: Generation of antibodies following immunization with DNA encoding human gp75TRP1, a tyrosinase family member expressed by melanomas, was accelerated and protection from tumor challenge augmented by GM-CSF DNA, whereas peptide immunization of control skin sites did not elicit any detectable T-cell responses.
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Strategies to overcome immune ignorance and tolerance.
Miguel-Angel Perales,Nathalie E. Blachere,Manuel E. Engelhorn,Cristina R. Ferrone,Jason S. Gold,Polly D. Gregor,Gabriele Noffz,Jedd D. Wolchok,Alan N. Houghton +8 more
TL;DR: In this review, strategies to overcome immune ignorance and tolerance are discussed and several strategies for developing effective tumor immunity are developed.
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