Manon Benabides
French Institute of Health and Medical Research
9 Papers
Manon Benabides is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of Manon Benabides include Université Paris-Saclay.
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Papers
The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles.
Margot Jarrige,Margot Jarrige,Elie Frank,Elie Frank,Elise Herardot,Elise Herardot,Sabrina Martineau,Sabrina Martineau,Annabelle Darle,Annabelle Darle,Manon Benabides,Manon Benabides,Sophie Domingues,Sophie Domingues,Olivier Chose,Olivier Chose,Walter Habeler,Walter Habeler,Judith Lorant,Judith Lorant,Christine Baldeschi,Christine Baldeschi,Cécile Martinat,Cécile Martinat,Christelle Monville,Christelle Monville,Lise Morizur,Lise Morizur,Karim Ben M'Barek,Karim Ben M'Barek +29 more
TL;DR: In this paper, the state of the art of regenerative medicine and its current limitations and challenges are discussed, with particular attention on pluripotent stem cell-derived products to repair organs like the eye, heart, skeletal muscle and skin.
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Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation.
Lucile Hoch,Sara F. Henriques,Celine Bruge,Justine Marsolier,Manon Benabides,Nathalie Bourg,Johana Tournois,Gurvan Mahé,Lise Morizur,Margot Jarrige,Anne Bigot,Isabelle Richard,Xavier Nissan +12 more
TL;DR: The first in vitro model for LGMD2D that is compatible with high-throughput screening is reported on and a new therapeutic option is proposed for LG MD2D caused by missense mutations of α-SG is proposed.
Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination
Lucile Hoch,Nathalie Bourg,Fanny Degrugillier,Celine Bruge,Manon Benabides,Emilie Pellier,Johana Tournois,Gurvan Mahé,N. Maignan,Jack Dawe,Maxime Georges,D Papazian,Nik Subramanian,Stéphanie Simon,Pascale Fanen,Cédric Delevoye,Isabelle Richard,Xavier Nissan +17 more
TL;DR: Results shed light on the potential repurposing of givinostat for the treatment of other genetic diseases sharing similar protein degradation defects such as LGMD R5 and cystic fibrosis.
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Skeletal Muscle Cells Derived from Induced Pluripotent Stem Cells: A Platform for Limb Girdle Muscular Dystrophies
Celine Bruge,Marine Geoffroy,Manon Benabides,Emilie Pellier,Evelyne Gicquel,Jamila Dhiab,Lucile Hoch,Isabelle Richard,Xavier Nissan +8 more
TL;DR: A platform for modeling LGMD based on the use of human induced pluripotent stem cells (hiPSC) and it is reported that skMC derived from hiPSC express the majority of the genes and proteins causing LGMD.
High-throughput screening identifies bazedoxifene as a potential therapeutic for dysferlin-deficient limb girdle muscular dystrophy.
Celine Bruge,Nathalie Bourg,Emilie Pellier,Johana Tournois,Jerome Polentes,Manon Benabides,Noella Grossi,Anne Bigot,Anthony Brureau,Isabelle Richard,Xavier Nissan +10 more