Mandy Richter
Translational Centre for Regenerative Medicine
5 Papers
1 Citations
Mandy Richter is an academic researcher from Translational Centre for Regenerative Medicine. The author has contributed to research in topics: Biology & Immunology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Activation of distinct inflammatory pathways in subgroups of LR-MDS.
Marie Schneider,C.W. Rolfs,Matt Trumpp,Susann Winter,Luise Fischer,Mandy Richter,Victoria Menger,Kolja Nenoff,N. Grieb,Klaus H. Metzeler,Anne Sophie Kubasch,Katja Sockel,Christian Thiede,Jincheng Wu,Jang Hee Woo,A. Brüderle,Lorenz C. Hofbauer,Andreas Roth,Michael Cross,Uwe Platzbecker +19 more
TL;DR: In this article , a large, clinically and genetically well-characterized cohort of treatment-naïve MDS patients confirms intrinsic activation of inflammatory pathways in general mediated by caspase-1, interleukin (IL)-1β and IL-18 in low risk (LR)-MDS bone marrow and reveals a previously unrecognized heterogeneity of inflammation between genetically defined LR-MDS subgroups.
Molecular analyses of glioblastoma stem-like cells and glioblastoma tissue
Marco Wallenborn,Marco Wallenborn,Li-Xin Xu,Holger Kirsten,Leili Rohani,Leili Rohani,Daniela Rudolf,Peter Ahnert,Christian Schmidt,Christian Schmidt,Ronny M. Schulz,Ronny M. Schulz,Mandy Richter,Wolfgang Krupp,Wolf Mueller,Adiv A. Johnson,Jürgen Meixensberger,Heidrun Holland +17 more
TL;DR: Previously undescribed genomic and gene expression differences were detected when comparing tumor tissue and isolated stem-like subpopulations, demonstrating that upregulated genes in CD133pos./CD15pos cells are relevant to cell cycle processes and cancerogenesis.
Activation of Distinct Inflammatory Pathways in LR-MDS Is Determined By Genetics
Marie Schneider,C.W. Rolfs,Matt Trumpp,Susann Winter,Luise Fischer,Mandy Richter,Victoria Menger,Kolja Nenoff,N. Grieb,Anne Sophie Kubasch,Klaus H. Metzeler,Katja Sockel,Christian Thiede,Lorenz C. Hofbauer,Andreas Roth,Andreas Bruederle,J. Woo,Michael Cross,Uwe Platzbecker +18 more
TL;DR: In this article , a principle component analysis (PCA) was performed and a cumulative gene expression score was calculated as summed log 2 fold changes (mean non-CHIP = 0) of all 11 mRNA expression values for each sample.
2
Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)
Maria Llamazares Prada,U. Schwartz,Darius F. Pease,Stephanie Pohl,Deborah Ackesson,Renjiao Li,A. Behrendt,R. Tamas,Mandy Richter,Thomas Muley,Joschka Hey,E. Espinet,C. Heußel,A. Warth,Mark Schneider,H. Winter,F. Herth,Charles D. Imbusch,Benedikt Brors,V. Beneš,David M. Wyatt,Tomasz P. Jurkowski,H. Stahl,C. Plass,RZ Jurkowska +24 more
TL;DR: The findings suggest that COPD-triggered epigenetic alterations in AT2 cells may impair internal regeneration programs in human lung parenchyma.
2
High-resolution transcriptomic and epigenetic profiling across disease stages identifies novel regulators of COPD phenotypes.
Llamazares Prada,Uwe Schwartz,Stephanie Pohl,Mandy Richter,Michael Schuller,Corinna Keller,Vedrana Mijošek,Thomas Muley,M. Schneider,Raluca Tamas,Karsten Quast,Joschka Hey,Claus Peter Heussel,Arne Warth,Hauke Winter,Harry Karmouty-Quintana,Felix J.F. Herth,Ina Koch,Dieter Weichenhan,Tomasz P. Jurkowski,Charles D. Imbusch,Benedikt Brors,Vladimir Benes,Brigit Jung,Heiko Stahl,David Michael Wyatt,Christoph Plass,Renata Z. Jurkowska +27 more
- 10 Mar 2022
TL;DR: In this article , the authors used bisulfite sequencing to generate genome-wide DNA methylation maps at single CpG resolution of parenchymal fibroblasts and alveolar type 2 (AT2) cells across COPD stages.