Mandar Deepak Muzumdar
Yale University
41 Papers
11 Citations
Mandar Deepak Muzumdar is an academic researcher from Yale University. The author has contributed to research in topics: KRAS & Medicine. The author has an hindex of 13, co-authored 20 publications. Previous affiliations of Mandar Deepak Muzumdar include Stanford University & Harvard University.
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Papers
A global double‐fluorescent Cre reporter mouse
Mandar Deepak Muzumdar,Bosiljka Tasic,Bosiljka Tasic,Kazunari Miyamichi,Kazunari Miyamichi,Ling Li,Ling Li,Liqun Luo,Liqun Luo +8 more
TL;DR: The mT/mG mouse as mentioned in this paper is a double-fluorescent Cre reporter mouse that expresses membrane-targeted tandem dimer tomato (mT) prior to Cre-mediated excision and membranetargeted green fluorescent protein (mG) after excision.
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.
Robert Machold,Shigemi Hayashi,Michael Rutlin,Mandar Deepak Muzumdar,Susana Vaz Nery,Joshua G. Corbin,Amel Gritli-Linde,Tammy Dellovade,Jeffery A. Porter,Lee L. Rubin,Henryk Dudek,Andrew P. McMahon,Gord Fishell +12 more
TL;DR: In this paper, conditional null alleles of both the Sonic hedgehog and Smoothened genes were examined to directly test the requirement for hedgehog signaling in the telencephalon from early neurogenesis.
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Mosaic Analysis with Double Markers in Mice
TL;DR: Cerebellar granule cell progenitors are fated at an early stage to produce granule cells with axonal projections limited to specific sublayers of the cerebellar cortex, showing that interchromosomal recombination can be induced efficiently in vivo in both mitotic and postmitotic cells in all tissues examined.
590
Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma
TL;DR: The preclinical data from human tissue, cell lines, and animal models that implicate c- MET in the pathogenesis of HCC are summarized and potential biomarkers that may estimate prognosis or predict response to c-MET inhibitors are evaluated for more rational clinical trial design.
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Survival of pancreatic cancer cells lacking KRAS function
Mandar Deepak Muzumdar,Mandar Deepak Muzumdar,Pan Yu Chen,Kimberly Judith Dorans,Katherine Minjee Chung,Arjun Bhutkar,Erin Hong,Elisa M. Noll,Martin R. Sprick,Andreas Trumpp,Tyler Jacks +10 more
TL;DR: In this article, the authors used CRISPR/Cas-mediated genome editing to demonstrate that KRAS is dispensable in a subset of human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.