Manchen Gao
Shanghai Jiao Tong University
7 Papers
6 Citations
Manchen Gao is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Tracheal Stenosis & Transplantation. The author has an hindex of 5, co-authored 7 publications.
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Papers
Long-segmental tracheal reconstruction in rabbits with pedicled Tissue-engineered trachea based on a 3D-printed scaffold.
TL;DR: The combination of in vitro pre-culture and in vivo pre-vascularization successfully generated a segmental tracheal substitute with bionic structure and mechanical properties similar to the native trachea of rabbits, presenting a promising approach for surgical reconstruction of long segmentaltracheal defects.
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Tissue-engineered trachea from a 3D-printed scaffold enhances whole-segment tracheal repair in a goat model.
Dekai Xia,Dawei Jin,Qian Wang,Manchen Gao,Jialing Zhang,Hengyi Zhang,Jie Bai,Bei Feng,Maolin Chen,Yanhui Huang,Yumin Zhong,Nevin Witman,Wei Wang,Zhiwei Xu,Haibo Zhang,Meng Yin,Wei Fu +16 more
TL;DR: This large animal study provides potential preclinical evidence around the employment of an orthotopic transplantation of a whole 3D‐printed TET for tracheal stenosis and an encouraging epithelial‐like tissue formation was observed in the TETs after transplantation.
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Kartogenin preconditioning commits mesenchymal stem cells to a precartilaginous stage with enhanced chondrogenic potential by modulating JNK and β-catenin–related pathways
Hui Jing,Xiaoyang Zhang,Manchen Gao,Kai Luo,Wei Fu,Meng Yin,Wei Wang,Zhongqun Zhu,Jinghao Zheng,Xiaomin He +9 more
TL;DR: KGN preconditioning likely improves the chondrogenic differentiation of hUCMSCs by committing them to a precartilaginous stage with enhanced JNK phosphorylation and suppressed β‐catenin levels.
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Evaluation of the potential of kartogenin encapsulated poly(L-lactic acid-co-caprolactone)/collagen nanofibers for tracheal cartilage regeneration.
Haiyue Yin,Juan Wang,Ziqi Gu,Feng Wenhao,Manchen Gao,Yu Wu,Hao Zheng,Hao Zheng,Xiaomin He,Xiumei Mo +9 more
TL;DR: The results suggested that the core-shell nanofibrous scaffold with kartogenin could promote the chondrogenic differentiation ability of bone marrow mesenchymal stem cells and served as a promising tissue engineered scaffold for tracheal cartilage regeneration.
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Restoring tracheal defects in a rabbit model with tissue engineered patches based on TGF-β3-encapsulating electrospun poly(l-lactic acid-co-ε-caprolactone)/collagen scaffolds.
Hui Jing,Botao Gao,Manchen Gao,Haiyue Yin,Xiumei Mo,Xiaoyang Zhang,Kai Luo,Bei Feng,Wei Fu,Jing Wang,Wei Zhang,Meng Yin,Zhongqun Zhu,Xiaomin He,Jinghao Zheng +14 more
TL;DR: TGF-β3-encapsulating core–shell electrospun scaffolds with a PLCL/collagen proportion of 75:25 could be used to optimize engineering process of tracheal patches to promote the chondrogenic differentiation of BMSCs and shorten the incubation time.
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