Mamoru Kanda
Kyoto University
45 Papers
239 Citations
Mamoru Kanda is an academic researcher from Kyoto University. The author has contributed to research in topics: Sterol O-acyltransferase & Receptor. The author has an hindex of 12, co-authored 45 publications.
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Papers
Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPARγ Agonists
Satoru Azukizawa,Masayasu Kasai,Kenji Takahashi,Tomohiro Miike,Kazuyoshi Kunishiro,Mamoru Kanda,Chisato Mukai,Hiroaki Shirahase +7 more
TL;DR: It is demonstrated that KY-021 has great potential as an efficacious and safe drug for diabetes and has little toxicity in male SD rats.
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Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2.
Hiroaki Shirahase,Mamoru Kanda,Kazuyoshi Kurahashi,Shohei Nakamura,Hachiro Usui,Yoshiharu Shimizu +5 more
TL;DR: In conclusion, SP at 10−8 m induces EDC via endothelial NK1 receptors and TXA2 production, and SP at10−7 m induces EIC via NK2 receptors in the rabbit intrapulmonary artery.
Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.
Kenji Takahashi,Masayasu Kasai,Masaru Ohta,Yoshimichi Shoji,Kazuyoshi Kunishiro,Mamoru Kanda,Kazuyoshi Kurahashi,Hiroaki Shirahase +7 more
TL;DR: Two novel indoline derivatives with an ionizable moiety showed good oral absorption and inhibitory activity against foam cell formation in THP-1 cells exposed to acetyl-LDL after differentiation and are a promising candidate for antihyperlipidemic and antiatherosclerotic drugs.
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Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice.
Yuma Ito,Masaki Fukui,Mamoru Kanda,Ko Morishita,Yoshimichi Shoji,Tatsuya Kitao,Eiichi Hinoi,Hiroaki Shirahase +7 more
TL;DR: In conclusion, KY-226 exerted anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
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Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.
Kazuya Otake,Satoru Azukizawa,Masaki Fukui,Kazuyoshi Kunishiro,Hikaru Kamemoto,Mamoru Kanda,Tomohiro Miike,Masayasu Kasai,Hiroaki Shirahase +8 more
TL;DR: In this article, a series of 1,2,3,4,tetrahydroisoquinoline-3-carboxylic acid derivatives were synthesized and (S)-2-[(2E,4E)-hexadienoyl]-7-(2-{5-methyl-2]-(1E)-5methylhexen-1-yl]oxazol-4-yl}ethoxy)-1,2.
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