Mamoru Hasegawa
Kyushu University
175 Papers
2.1K Citations
Mamoru Hasegawa is an academic researcher from Kyushu University. The author has contributed to research in topics: Sendai virus & Genetic enhancement. The author has an hindex of 43, co-authored 175 publications.
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Papers
Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
Noemi Fusaki,Hiroshi Ban,Akiyo Nishiyama,Koichi Saeki,Mamoru Hasegawa +4 more
- 01 Jan 2009
TL;DR: It is shown that Sendai virus (SeV), an RNA virus and carries no risk of altering host genome, is an efficient solution for generating safe iPSC and will accelerate the clinical application.
1.5K
Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors
Hiroshi Ban,Naoki Nishishita,Noemi Fusaki,Toshiaki Tabata,Koichi Saeki,Masayuki Shikamura,Nozomi Takada,Makoto Inoue,Mamoru Hasegawa,Shin Kawamata,Shin-Ichi Nishikawa +10 more
TL;DR: It is shown that Sendai virus vector, an RNA virus vector that carries no risk of integrating into the host genome, is a practical solution for the efficient generation of safer iPSCs and suggested that generation of transgene-free iPSCS from cord blood cells should be an important step in providing allogeneic iPSC-derived therapy in the future.
611
Generation of Induced Pluripotent Stem Cells from Human Terminally Differentiated Circulating T Cells
Tomohisa Seki,Shinsuke Yuasa,Mayumi Oda,Toru Egashira,Kojiro Yae,Dai Kusumoto,Hikari Nakata,Shugo Tohyama,Hisayuki Hashimoto,Masaki Kodaira,Yohei Okada,Hiroyuki Seimiya,Noemi Fusaki,Mamoru Hasegawa,Keiichi Fukuda +14 more
TL;DR: A manuscript has appeared online demonstrating isolation of iPSCs from peripheral blood, including a single line that showed evidence for both T CR-β and TCR-γ rearrangement by PCR.
606
Efficient gene transfer to airway epithelium using recombinant Sendai virus
Yoshikazu Yonemitsu,Christopher Kitson,Stefano Ferrari,R Farley,Uta Griesenbach,Diane Judd,Rachel M. Steel,Philippe Scheid,Jie Zhu,Peter K. Jeffery,Atsushi Kato,Mohammad K. Hasan,Yoshiyuki Nagai,Ichiro Masaki,Masayuki Fukumura,Mamoru Hasegawa,Duncan M. Geddes,Eric W.F.W. Alton +17 more
TL;DR: It is shown that recombinant Sendai virus (SeV) produces efficient transfection throughout the respiratory tract of both mice and ferrets in vivo, as well as in freshly obtained human nasal epithelial cells in vitro.
259
Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial.
Tetsuro Matano,Masahiro Kobayashi,Hiroko Igarashi,Akiko Takeda,Akiko Takeda,Hiromi Nakamura,Munehide Kano,Chie Sugimoto,Kazuyasu Mori,Akihiro Iida,Takahiro Hirata,Mamoru Hasegawa,Takae Yuasa,Masaaki Miyazawa,Yumiko Takahashi,Michio Yasunami,Akinori Kimura,David H. O’Connor,David I. Watkins,Yoshiyuki Nagai +19 more
TL;DR: Evidence is shown suggesting that vaccine-induced CTLs control SIVmac239 replication in rhesus macaques and results indicate that vaccine induction of highly effective C TLs can result in the containment of replication of a highly pathogenic immunodeficiency virus.