Mami Takahashi
National Cancer Research Institute
113 Papers
1.4K Citations
Mami Takahashi is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Azoxymethane & Carcinogenesis. The author has an hindex of 35, co-authored 110 publications. Previous affiliations of Mami Takahashi include Merck & Co..
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Papers
•Journal Article
Involvement of Prostaglandin E Receptor Subtype EP4 in Colon Carcinogenesis
Michihiro Mutoh,Kouji Watanabe,Tomohiro Kitamura,Yutaka Shoji,Mami Takahashi,Toshihiko Kawamori,Kousuke Tani,Michiyoshi Kobayashi,Takayuki Maruyama,Kaoru Kobayashi,Shuichi Ohuchida,Yukihiko Sugimoto,Shuh Narumiya,Takashi Sugimura,Keiji Wakabayashi +14 more
TL;DR: Results indicate that PGE(2) contributes to colon carcinogenesis through its actions mediated through EP(1) and EP(4) receptors; therefore, antagonists for these two receptors may be good candidates as chemopreventive agents against colon cancer.
400
Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells.
TL;DR: The cloning and functional expression of a complementary DNA encoding a rat ECE from endothelial cells is reported, revealing that ECE messenger RNA is widely expressed in many tissues.
301
•Journal Article
β-Catenin Is Frequently Mutated and Demonstrates Altered Cellular Location in Azoxymethane-induced Rat Colon Tumors
TL;DR: Investigation of mutations of the beta-catenin gene in azoxymethane-induced rat colon tumors revealed eight mutations in six of the eight colon carcinomas, and seven of these were shown to be G:C to A:T transitions, with five being CTGGA to CTGAA.
209
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure
Michihiro Mutoh,Mami Takahashi,Kazunori Fukuda,Yuko Matsushima-Hibiya,Hiroshi Mutoh,Takashi Sugimura,Keiji Wakabayashi +6 more
TL;DR: In the present study, a beta-galactosidase reporter gene system is constructed in human colon cancer DLD-1 cells, and COX-2 promoter-dependent transcriptional activity in the cells is measured, finding Chemopreventive agents such as quercetin, kaempferol, genistein, resveratrol and resorcinol, all having a common Resorcin moiety, were found to effectively suppress the COX2 promoter activity
192
Altered expression of β-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis
TL;DR: Results show that beta-catenin alterations may be related to induction of iNOS expression, these being early events in AOM-induced colon tumorigenesis which may play important roles in causing dysplastic changes.