Malorie Greene
University of Paris
4 Papers
Malorie Greene is an academic researcher from University of Paris. The author has contributed to research in topics: Microsatellite instability & Exome sequencing. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Malorie Greene include Pierre-and-Marie-Curie University.
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Papers
HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer
Olivier Buhard,Anaïs Lagrange,Agathe Guilloux,Chrystelle Colas,Mouna Chouchène,Kristell Wanherdrick,Florence Coulet,Erell Guillerm,Coralie Dorard,Laetitia Marisa,A’dem Bokhari,Malorie Greene,Nizar El-Murr,Sahra Bodo,Martine Muleris,Isabelle Sourouille,Magali Svrcek,Pascale Cervera,Hélène Blanché,Jérémie H. Lefevre,Yann Parc,Côme Lepage,Caroline Chapusot,Anne-Marie Bouvier,Marie-Pierre Gaub,Janick Selves,Kerryn Garrett,Barry Iacopetta,Richie Soong,Richard Hamelin,Carmen Garrido,Olivier Lascols,Thierry André,Jean-François Fléjou,Ada Collura,Alex Duval +35 more
TL;DR: HT17 simplifies and improves the current standard molecular methods for detecting MSI in CRC and showed excellent ability to detect MSI in patients with LS.
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Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability.
Vincent Jonchère,Laetitia Marisa,Malorie Greene,Alain Virouleau,Alain Virouleau,Olivier Buhard,Romane Bertrand,Magali Svrcek,Pascale Cervera,Anastasia R. Goloudina,Erell Guillerm,Florence Coulet,Samuel Landman,Toky Ratovomanana,Sylvie Job,Mira Ayadi,Nabila Elarouci,Lucile Armenoult,Fatiha Merabtene,Sylvie Dumont,Yann Parc,Jérémie H. Lefevre,Thierry André,Jean-François Fléjou,Agathe Guilloux,Ada Collura,Aurélien de Reyniès,Alex Duval +27 more
TL;DR: The present results identify the positive and negative driver somatic mutations acting in MSI-driven tumorigenesis, suggesting that genomic instability in MSI CRC plays a dual role in achieving tumor cell transformation.
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Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability Positive Selection Pressure Mutational Background Negative Selection Pressure Mutational Frequency Microsatellite length (bp)
Vincent Jonchère,Laetitia Marisa,Malorie Greene,Alain Virouleau,Olivier Buhard,Romane Bertrand,Magali Svrcek,Pascale Cervera,Anastasia R. Goloudina,Erell Guillerm,Florence Coulet,Samuel Landman,Toky Ratovomanana,Sylvie Job,Mira Ayadi,Nabila Elarouci,Lucile Armenoult,Fatiha Merabtene,Sylvie Dumont,Y. Parc,Jérémie H. Lefevre,Thierry André,Jean-François Fléjou,Agathe Guilloux,Ada Collura,Aurélien de Reyniès,Alex Duval +26 more
- 01 Jan 2018
TL;DR: The present results identify the positive and negative driver somatic mutations acting in MSI-driven tumorigenesis, suggesting that genomic instability in MSI CRC plays a dual role in achieving tumor cell transformation.
3
Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability.
A’dem Bokhari,Vincent Jonchère,Anaïs Lagrange,Romane Bertrand,Magali Svrcek,Laetitia Marisa,Olivier Buhard,Malorie Greene,Anastasia Demidova,Jieshuang Jia,Eric Adriaenssens,Thierry Chassat,Denis Biard,Jean-François Fléjou,Fabrice Lejeune,Alex Duval,Ada Collura +16 more
- 19 Sep 2018
TL;DR: Inhibition of NMD in vivo using amlexanox reduced MSI tumor growth, but not that of MSS tumors, suggesting that inhibition of the oncogenic activity of N MD may be an effective strategy for the personalized treatment of MSI CRC.