Malcolm Lim
Boston Children's Hospital
4 Papers
21 Citations
Malcolm Lim is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Anaplastic lymphoma kinase & CISH. The author has an hindex of 3, co-authored 4 publications.
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Papers
Identification of MET genomic amplification, protein expression and alternative splice isoforms in neuroblastomas
Benedict Yan,Benedict Yan,Malcolm Lim,Lihan Zhou,Chik Hong Kuick,May Ying Leong,Kol Jia Yong,LeLe Aung,Manuel Salto-Tellez,Manuel Salto-Tellez,Kenneth T E Chang +10 more
TL;DR: MET amplification and protein expression, although low in prevalence, are present in neuroblastomas, and the existence of alternatively spliced MET isoforms may have clinical and biological implications in Neuroblastomas.
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Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas.
Benedict Yan,Chik Hong Kuick,Malcolm Lim,Kavita Venkataraman,Chandana Tennakoon,Eva Loh,Derrick W. Q. Lian,May Ying Leong,Manikandan Lakshmanan,Vinay Tergaonkar,Wing-Kin Sung,Shui Yen Soh,Kenneth T E Chang +12 more
TL;DR: D5F3 immunohistochemistry, single-color CISH and IT-PGM sequencing are suitable assays for evaluation of ALK status in future neuroblastoma clinical trials, and correlation with ALK genomic and hotspot mutational status revealed that the majority of D5F2 ALK-positive cases did not possess either ALK genomes or hotspot mutations.
Neuronal defects an etiological factor in congenital pelviureteric junction obstruction
Guo Yuan How,Kenneth Tou En Chang,Anette Sundfor Jacobsen,Te-Lu Yap,Caroline C P Ong,Yee Low,John Carson Allen,Chik Hong Kuick,Malcolm Lim,Narasimhan Kannan Laksmi +9 more
TL;DR: The results show no clinical significance of the expression of neuronal markers in predicting degree of pre-operative renal pelvis dilation or differential renal function, and the heterogeneity of expression of neurons in PUJO specimens and controls in the population is at variance with prior studies.
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Characterization of anaplastic lymphoma kinase-positive medulloblastomas
Benedict Yan,Chik Hong Kuick,Malcolm Lim,Min Hwee Yong,Chi Kuen Lee,Sharon Y.Y. Low,David C.Y. Low,Diana Lim,Shui Yen Soh,Kenneth Tou En Chang +9 more
TL;DR: The expression of anaplastic lymphoma kinase (ALK), a well-characterized tyrosine kinase and drug target, is studied in a cohort of medulloblastomas by immunohistochemistry and identified three ALK-positive cases.
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