Malbora Manne
Memorial Sloan Kettering Cancer Center
4 Papers
1 Citations
Malbora Manne is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Internal medicine & Germline mutation. The author has an hindex of 3, co-authored 4 publications.
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Papers
Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma.
Christian Grommes,Christian Grommes,Sarah S. Tang,Julia Wolfe,Thomas Kaley,Mariza Daras,Elena Pentsova,Anna F. Piotrowski,Jacqueline B. Stone,Andrew L. Lin,Craig Nolan,Malbora Manne,Paolo Codega,Carl Campos,Agnes Viale,Alissa A. Thomas,Michael F. Berger,Michael F. Berger,Vaios Hatzoglou,Anne S. Reiner,Katherine S. Panageas,Lisa M. DeAngelis,Ingo K. Mellinghoff +22 more
TL;DR: The combination of ibrutinib, HD-MTX, and rituximab was tolerated with an acceptable safety profile and sustained tumor responses were associated with clearance of ctDNA from the CSF.
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Genomic correlates of disease progression and treatment response in prospectively characterized gliomas
Philip Jonsson,Andrew L. Lin,Robert J. Young,Natalie DiStefano,David M. Hyman,Bob T. Li,Michael F. Berger,Ahmet Zehir,Marc Ladanyi,David B. Solit,Angela G. Arnold,Zsofia K. Stadler,Diana Mandelker,Michael E. Goldberg,Juliann Chmielecki,Maryam Pourmaleki,Shahiba Ogilvie,Shweta S. Chavan,Andrew T. McKeown,Malbora Manne,Allison Hyde,Kathryn Beal,T. Jonathan Yang,Craig Nolan,Elena Pentsova,Antonio Omuro,Igor T. Gavrilovic,Thomas Kaley,Eli L. Diamond,Jacqueline B. Stone,Christian Grommes,Adrienne Boire,Mariza Daras,Anna F. Piotrowski,Alexandra Miller,Philip H. Gutin,Timothy A. Chan,Viviane Tabar,Cameron Brennan,Marc K. Rosenblum,Lisa M. DeAngelis,Ingo K. Mellinghoff,Barry S. Taylor +42 more
TL;DR: These data reveal genomic correlates of disease progression and treatment response in diverse types of glioma and highlight the potential utility of incorporating genomic information into the clinical decision-making for patients with gliomas.
New model of care for patients with central nervous system cancers.
Elena Pentsova,Kathryn S. Nevel,Franchesca Konig,Maryann Sibilla,Anna Skakodub,Malbora Manne,Mimma Errante,Milagros Gordilo,Gayle Rawlins-Peters,Dominique Jean-Charles,Anastasia Zankowsky,Jody Gilman,Brian Kelly,Stephanie Zavolas,Hannah Goldman,Grigory Syrkin,Eli L. Diamond,Lisa M. DeAngelis,Lisa Marie Ruppert,Alan Carver +19 more
TL;DR: A large number of patients with primary or metastatic central nervous system (CNS) cancers often have multiple physical, psychosocial, and spiritual needs, and neurological impairments can ...
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Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.
Antonio Omuro,Kathryn Beal,Katharine McNeill,Robert J. Young,Alissa A. Thomas,Xuling Lin,Robert Terziev,Thomas Kaley,Lisa M. DeAngelis,Mariza Daras,I. T. Gavrilovic,Ingo K. Mellinghoff,Eli L. Diamond,Andrew T. McKeown,Malbora Manne,Andrew Caterfino,Krishna Patel,Linda M Bavisotto,Greg Gorman,Michael Lamson,Philip H. Gutin,Viviane Tabar,Debyani Chakravarty,Timothy A. Chan,Cameron Brennan,Elizabeth Garrett-Mayer,Rashida A. Karmali,Elena Pentsova +27 more
TL;DR: CTO can be combined safely with TMZ or chemoradiation in GBM and anaplastic gliomas, displaying favorable brain penetration and promising signals of activity in this difficult-to-treat population.