Maksim A. Shlykov
University of Michigan
21 Papers
29 Citations
Maksim A. Shlykov is an academic researcher from University of Michigan. The author has contributed to research in topics: Permease & Transport protein. The author has an hindex of 8, co-authored 18 publications. Previous affiliations of Maksim A. Shlykov include University of California, San Diego & University of California, Los Angeles.
Chat about Author
Papers
The major facilitator superfamily (MFS) revisited
TL;DR: The evolutionary origins of the major facilitator superfamily of secondary carriers are probed, providing evidence that they arose from a single 2‐transmembrane segment (TMS) hairpin structure that triplicated to give a 6‐TMS unit that duplicated to a 12 TMS protein, the most frequent topological type of these permeases.
482
The amino acid-polyamine-organocation superfamily.
Foon H. Wong,Jonathan S. Chen,Vamsee S. Reddy,Jonathan Day,Maksim A. Shlykov,Steven T. Wakabayashi,Milton H. Saier +6 more
TL;DR: Although the topology of the members of the APC superfamily differs from that of the MFS, both families appear to have arisen from a common ancestral 2 TMS hairpin structure that underwent intragenic triplication followed by loss of a TMS in theAPC family, to give the repeat units that are characteristic of these two superfamilies.
The transporter-opsin-G protein-coupled receptor (TOG) superfamily.
Daniel C. Yee,Maksim A. Shlykov,Åke Västermark,Vamsee S. Reddy,Sumit Arora,Eric I. Sun,Milton H. Saier +6 more
TL;DR: It is shown that the TSUP, GPCR and microbial rhodopsin families are related to each other and to six other currently recognized transport protein families, and this superfamily is designated the transporter/opsin/G protein‐coupled receptor (TOG) superfamily.
Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters.
Wei Hao Zheng,Wei Hao Zheng,Åke Västermark,Maksim A. Shlykov,Maksim A. Shlykov,Vamsee S. Reddy,Vamsee S. Reddy,Eric I. Sun,Eric I. Sun,Milton H. Saier +9 more
TL;DR: Almost all integral membrane uptake porters of the ABC superfamily belong to the ABC2 family, previously established for exporters, and evolutionary pathways for their appearance are proposed.
Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins.
TL;DR: A novel program is developed, TM-STATS, that tabulates HMMTOP, SPOCTOPUS or MEMSAT-based topological predictions for any subdivision (class, subclass, superfamily, family, subfamily, or any combination of these) of the Transporter Classification Database (TCDB; www.tcdb.org).