Makoto Hamada
Taisho Pharmaceutical Co.
16 Papers
24 Citations
Makoto Hamada is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Substituent & Heterocyclic compound. The author has an hindex of 4, co-authored 16 publications.
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Papers
Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists.
Matsuda Daisuke,Yohei Kobashi,Ayako Mikami,Madoka Kawamura,Fumiyasu Shiozawa,Kenichi Kawabe,Makoto Hamada,Koji Oda,Shinichi Nishimoto,Kayo Kimura,Masako Miyoshi,Noriko Takayama,Hiroyuki Kakinuma,Norikazu Ohtake +13 more
TL;DR: Design and synthesis of a novel class of 1H-pyrazolo[3,4-c]pyridine GPR119 receptor agonists are described and lead compound 4 was identified through the ligand-based drug design approach.
18
Patent
Partially saturated nitrogen-containing heterocyclic compound
Tetsuo Takayama,Tsuyoshi Shibata,Fumiyasu Shiozawa,Kenichi Kawabe,Yuki Shimizu,Makoto Hamada,Akira Hiratate,Masato Takahashi,Fumihito Ushiyama,Takahiro Oi,Yoshihisa Shirasaki,Matsuda Daisuke,Chie Koizumi,Sota Kato +13 more
- 29 Jul 2013
TL;DR: In this article, a compound which is represented by general formula (I') and has an excellent PHD2-inhibiting activity or a pharmaceutically acceptable salt thereof is provided.
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Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia.
Makoto Hamada,Tetsuo Takayama,Tsuyoshi Shibata,Akira Hiratate,Masato Takahashi,Miyoko Yashiro,Noriko Takayama,Lisa Okumura-Kitajima,Hiroko Koretsune,Hiromitsu Kajiyama,Takumi Naruse,Sota Kato,Hiroki Takano,Hiroyuki Kakinuma +13 more
TL;DR: Novel PHD inhibitor 1 with a 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid motif is found, demonstrated to promote the production of erythropoietin (EPO) following oral administration in mice and rats.
11
Patent
Azole-substituted pyridine compound
Hiroaki Tanaka,Bohno Ayako,Makoto Hamada,Ito Yuji,Yohei Kobashi,Madoka Kawamura +5 more
- 28 Mar 2019
TL;DR: In this paper, the authors present a compound represented by formula [I'| shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme.
4
Patent
Heteroaryl compound substituted by triazolyl
Yoichiro Suga,Yuki Shimizu,Kenichi Kawabe,Bohno Ayako,Makoto Hamada,Masato Takahashi +5 more
- 29 Oct 2015
TL;DR: In this article, the present invention provides a compound represented by formula (I) having a PHD-2-inhibiting action or a pharmacologically acceptable salt thereof (I).
3